Phosphine Oxide-Promoted Rh(I)-Catalyzed C-H Cyclization of Benzimidazoles with Alkenes

被引：2

作者：

Lu, Mingzhen ^{[1
]}

Xu, Weiwei ^{[1
]}

Ye, Mengchun ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Chem, Frontiers Sci Ctr New Organ Matter, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China

[2] Haihe Lab Sustainable Chem Transformat, Tianjin 300192, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 02期

基金：

中国国家自然科学基金;

关键词：

rhodium; C-H activation; benzimidazole; bimetal; phosphine oxide; BOND ACTIVATION; FUNCTIONALIZATION; HETEROCYCLES; SILYLATION; COMPLEXES;

D O I：

10.3390/molecules28020736

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ligands play a critical role in promoting transition-metal-catalyzed C-H activation reactions. However, owing to high sensitivity of the reactivity of C-H activation to metal catalysts, the development of effective ligands has been a formidable challenge in the field. Rh(I)-catalyzed C-H cyclization of benzimidazoles with alkenes has been faced with low reactivity, often requiring very harsh conditions. To address this challenge, a phosphine oxide-enabled Rh(I)-Al bimetallic catalyst was developed for the reaction, significantly promoting the reactivity and allowing the reaction to run at 120 degrees C with up to 97% yield.

引用

页数：10

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