Applications of Optical Fiber in Label-Free Biosensors and Bioimaging: A Review

被引：19
作者：
Li, Baocheng [1 ]
Zhang, Ruochong [1 ]
Bi, Renzhe [1 ]
Olivo, Malini [1 ]
机构：
[1] ASTAR, Inst Bioengn & Bioimaging, Translat Biophoton Lab, Singapore 138667, Singapore
来源：
BIOSENSORS-BASEL | 2023年 / 13卷 / 01期
关键词：
biosensor; bioimaging optical fiber biosensor; surface plasmon resonance; Mach-Zehnder interferometer; fiber Bragg grating; photoacoustic imaging; SURFACE-PLASMON RESONANCE; HIGH-SENSITIVITY; SAGNAC-INTERFEROMETER; SENSOR; MODE; ULTRASOUND; TECHNOLOGY; GRATINGS; SILVER; SERS;
D O I：
10.3390/bios13010064
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Biosensing and bioimaging are essential in understanding biological and pathological processes in a living system, for example, in detecting and understanding certain diseases. Optical fiber has made remarkable contributions to the biosensing and bioimaging areas due to its unique advantages of compact size, immunity to electromagnetic interference, biocompatibility, fast response, etc. This review paper will present an overview of seven common types of optical fiber biosensors and optical fiber-based ultrasound detection in photoacoustic imaging (PAI) and the applications of these technologies in biosensing and bioimaging areas. Of course, there are many types of optical fiber biosensors. Still, this paper will review the most common ones: optical fiber grating, surface plasmon resonance, Sagnac interferometer, Mach-Zehnder interferometer, Michelson interferometer, Fabry-Perot Interferometer, lossy mode resonance, and surface-enhanced Raman scattering. Furthermore, different optical fiber techniques for detecting ultrasound in PAI are summarized. Finally, the main challenges and future development direction are briefly discussed.
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页数：27
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