Hereditary Diffuse Gastric Cancer Treated by Prophylactic Total Gastrectomy

被引：1

作者：

Inaba, Yasunori ^{[1
]}

Goda, Kenichi ^{[1
]}

Kondo, Masayuki ^{[1
]}

Abe, Keiichiro ^{[1
]}

Kanamori, Akira ^{[1
]}

Suzuki, Tsunehiro ^{[1
]}

Tominaga, Keiichi ^{[1
]}

Nakagawa, Masatoshi ^{[2
]}

Morita, Shinji ^{[2
]}

Kojima, Kazuyuki ^{[2
]}

Ishida, Kazuyuki ^{[3
]}

Irisawa, Atsushi ^{[1
]}

机构：

[1] Dokkyo Med Univ, Dept Gastroenterol, Mibu, Japan

[2] Dokkyo Med Univ, Dept Upper Gastrointestinal Surg, Mibu, Japan

[3] Dokkyo Med Univ, Dept Diagnost Pathol, Mibu, Japan

来源：

INTERNAL MEDICINE | 2024年 / 63卷 / 02期

关键词：

hereditary diffuse gastric cancer; CDH1; signet ring cell carcinoma; endoscopic submucosal dissection; prophylactic gastrectomy; GUIDELINES;

D O I：

10.2169/internalmedicine.1257-22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a rare case of hereditary diffuse gastric cancer in a Japanese man. A 41-year-old man underwent esophagogastroduodenoscopy which revealed a small gastric erosion. Biopsy specimens showed signet ring cell carcinoma, and endoscopic submucosal dissection was performed. The patient's elder sister had died of gastric cancer at 38 years old. Considering the family history, a genetic test was conducted and revealed a CDH1 germline mutation. Although no carcinomatous lesion was detected endoscopically, prophylactic total gastrectomy was performed. The resection specimen showed seven microlesions of signet ring cell carcinoma confined to the lamina propria mucosae.

引用

页码：235 / 239

页数：5

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