Insights in orthodontic genetic and epigenetic knowledge and its translation in clinical practice

被引：2
作者：
Shirinian, Margret [1 ]
Yazbek, Soha [2 ]
Genno, Pamela [3 ]
机构：
[1] Amer Univ Beirut, Fac Med, Dept Expt Pathol Immunol & Microbiol, Beirut 11072020, Lebanon
[2] Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, Beirut 11072020, Lebanon
[3] Amer Univ Beirut, Fac Med, Dept Dentofacial Med, Beirut 11072020, Lebanon
来源：
SEMINARS IN ORTHODONTICS | 2023年 / 29卷 / 03期
关键词：
Genetics; Epigenetics; Biomarkers; Phenotype; Biological variation; MANDIBULAR PROGNATHISM; CEPHALOMETRIC VARIABLES; ASSOCIATION; HERITABILITY; MUTATIONS; IDENTIFICATION; TRANSPOSITION; POLYMORPHISMS; CANINE;
D O I：
10.1053/j.sodo.2023.06.003
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Applying genetic practice to current medicine has become more common and necessary in the prognosis, diagnosis and outcome of a myriad of diseases and disorders. Despite the general awareness of its importance, genetic knowledge still lacks direct application in daily orthodontic practice. The aim was to identify multiple genetic associations with orofacial phenotypes, highlight the importance of genetic influence in orthodontics, and describe challenges and gaps in integrating genetic knowledge in clinical practice. In the process, the influence of environmental factors on orofacial development and treatment is underscored, hence the role of epigenetics in regulating gene expression and tissue remodeling.
引用
收藏
页码：260 / 263
页数：4
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