Mitochondrial oxidative stress, mitochondrial ROS storms in long COVID pathogenesis

被引：11

作者：

Noonong, Kunwadee ^{[1
,2
]}

Chatatikun, Moragot ^{[1
,3
]}

Surinkaew, Sirirat ^{[1
,3
]}

Kotepui, Manas ^{[1
]}

Hossain, Rahni ^{[1
]}

Bunluepuech, Kingkan ^{[4
]}

Noothong, Chanittha ^{[1
]}

Tedasen, Aman ^{[1
,2
]}

Klangbud, Wiyada Kwanhian ^{[1
,2
]}

Imai, Motoki ^{[5
,6
]}

Kawakami, Fumitaka ^{[6
,7
,8
]}

Kubo, Makoto ^{[6
,9
,10
]}

Kitagawa, Yoshimasa ^{[11
]}

Ichikawa, Hiroshi ^{[12
]}

Kanekura, Takuro ^{[13
]}

Sukati, Suriyan ^{[1
]}

Somsak, Voravuth ^{[1
,2
]}

Udomwech, Lunla ^{[4
]}

Ichikawa, Takafumi ^{[6
,7
]}

Nissapatorn, Veeranoot ^{[1
,2
]}

Tangpong, Jitbanjong ^{[1
,2
]}

Indo, Hiroko P. ^{[14
,15
]}

Majima, Hideyuki J. ^{[1
,2
]}

机构：

[1] Walailak Univ, Sch Allied Hlth Sci, Nakhon Si Thammarat, Thailand

[2] Walailak Univ, Res Excellence Ctr Innovat & Hlth Prod RECIHP, Sch Allied Hlth Sci, Nakhon Si Thammarat, Thailand

[3] Walailak Univ, Ctr Excellence Res Melioidosis & Microorganisms, Nakhon Si Thammarat, Thailand

[4] Walailak Univ, Sch Med, Nakhon Si Thammarat, Thailand

[5] Kitasato Univ, Sch Allied Hlth Sci, Dept Mol Diagnost, Sagamihara, Japan

[6] Kitasato Univ, Sch Allied Hlth Sci, Regenerat Med & Cell Design Res Facil, Sagamihara, Japan

[7] Kitasato Univ, Grad Sch Med Sci, Dept Regulat Biochem, Sagamihara, Japan

[8] Kitasato Univ, Sch Allied Hlth Sci, Dept Hlth Adm, Sagamihara, Japan

[9] Kitasato Univ, Sch Allied Hlth Sci, Div Microbiol, Sagamihara, Japan

[10] Kitasato Univ, Grad Sch Med Sci, Dept Environm Microbiol, Sagamihara, Japan

[11] Hokkaido Univ, Grad Sch Dent Med, Div Oral Pathobiol Sci, Oral Diag & Med, Sapporo, Japan

[12] Doshisha Univ, Grad Sch Life & Med Sci, Kyoto, Japan

[13] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Dermatol, Kagoshima, Japan

[14] Kagoshima Univ, Dept Oncol, Dept Radiol, Grad Sch Med & Dent Sci, Kagoshima, Japan

[15] Kagoshima Univ, Amanogawa Galaxy Astron Res Ctr, Grad Sch Engn, Kagoshima, Japan

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

COVID-19; oxidative stress; mitochondrial ROS storms; long Covid; mitochondria; DIABETES-MELLITUS; INJURY;

D O I：

10.3389/fimmu.2023.1275001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Significance: This review discusses the coronavirus disease 2019 (COVID-19) pathophysiology in the context of diabetes and intracellular reactions by COVID-19, including mitochondrial oxidative stress storms, mitochondrial ROS storms, and long COVID. Recent advances: The long COVID is suffered in similar to 10% of the COVID-19 patients. Even the virus does not exist, the patients suffer the long COVID for even over a year, This disease could be a mitochondria dysregulation disease. Critical issues: Patients who recover from COVID-19 can develop new or persistent symptoms of multi-organ complications lasting weeks or months, called long COVID. The underlying mechanisms involved in the long COVID is still unclear. Once the symptoms of long COVID persist, they cause significant damage, leading to numerous, persistent symptoms. Future directions: A comprehensive map of the stages and pathogenetic mechanisms related to long COVID and effective drugs to treat and prevent it are required, which will aid the development of future long COVID treatments and symptom relief.

引用

页数：10

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