The Effects of the Low Molecular Weight Nerve Growth Factor Mimetic GK-2 on Cognitive Function and Synaptic Transmission in Hippocampal Slices

被引：0

作者：

Volkova, A. A. ^{[1
,3
]}

Povarnina, P. Yu. ^{[1
]}

Rogozin, P. D. ^{[2
]}

Kondratenko, R. V. ^{[2
]}

Sharonova, I. N. ^{[2
]}

Kamenskii, A. A. ^{[3
]}

Skrebitskii, V. G. ^{[2
]}

机构：

[1] Zakusov Res Inst Pharmacol, Moscow, Russia

[2] Res Ctr Neurol, Moscow, Russia

[3] Moscow MV Lomonosov State Univ, Dept Biol, Moscow, Russia

来源：

NEUROCHEMICAL JOURNAL | 2023年 / 17卷 / 02期

关键词：

acute hippocampal slices; PPR; low-molecular-weight NGF mimetic; novel object recognition test; DIPEPTIDE MIMETICS; LOOP; 4; NGF; BDNF; HORMESIS; MEMORY; MODEL;

D O I：

10.1134/S1819712423020186

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nerve growth factor (NGF) contributes to the proliferation, differentiation, and maintenance of the viability and functioning of peripheral and central neurons. At the Zakusov Research Institute of Pharmacology, a dimeric dipeptide mimetic of the NGF loop 4 bis-(monosuccinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2) was created. GK-2 activates PI3K/AKT and PLC-gamma 1 signaling cascades, without affecting MAPK/ERK, and appears to have procognitive properties. In the present study, we investigated the mnemotropic effects of GK-2 with a single intraperitoneal dose of 0.1, 0.5, and 5.0 mg/kg in the novel object recognition test in rats. GK-2 at a dose of 0.5 mg/kg significantly improved the long-term memory of animals. In experiments with acute hippocampal slices of rats, we evaluated the effects of GK-2 on synaptic transmission and its plastic properties in the Schaffer collaterals-CA1 pyramidal cell synaptic system.

引用

页码：219 / 223

页数：5

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