Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment

被引：23

作者：

Pepin, Marion ^{[1
,2
,3
]}

Klimkowicz-Mrowiec, Aleksandra ^{[4
]}

Godefroy, Olivier ^{[5
,6
]}

Delgado, Pilar ^{[7
]}

Carriazo, Sol ^{[8
]}

Ferreira, Ana Carina ^{[9
,10
]}

Golenia, Aleksandra ^{[11
]}

Malyszko, Jolanta ^{[12
]}

Grodzicki, Tomasz ^{[4
]}

Giannakou, Konstantinos ^{[13
]}

Paolisso, Giuseppe ^{[14
,15
]}

Barbieri, Michelangela ^{[14
]}

Garneata, Liliana ^{[16
]}

Mocanu, Carmen Antonia ^{[16
]}

Liabeuf, Sophie ^{[17
,18
]}

Spasovski, Goce ^{[19
]}

Zoccali, Carmine ^{[20
,21
]}

Bruchfeld, Annette ^{[22
,23
]}

Farinha, Ana ^{[24
]}

Arici, Mustafa ^{[25
]}

Capasso, Giovambattista ^{[26
,27
]}

Wiecek, Andrzej A. ^{[28
]}

Massy, Ziad ^{[1
,2
,29
]}

机构：

[1] Paris Saclay Univ, Hop Paul Brousse, INSERM Inst Natl Sante & Rech Med Unit 1018, Clinical Epidemiol,CESP Ctr Epidemiol & Sante Popu, Villejuif, France

[2] Versailles St Quentin En Yvelines Univ, Villejuif, France

[3] Ambroise Pare Univ Hosp, AP HP Assistance Publ Hop Paris, Dept Geriatr, 9 Ave Charles de Gaulle, F-92100 Boulogne Billancourt Pari, France

[4] Jagiellonian Univ Med Coll, Dept Internal Med & Gerontol, Krakow, Poland

[5] Jules Verne Univ Picardie UPJV, Amiens Univ Hosp, Dept Neurol, Amiens, France

[6] Jules Verne Univ Picardie UPJV, Res Unit 4559, Lab Funct Neurosci, Amiens, France

[7] Univ Autonoma Barcelona, Vall dHebron Hosp, Dept Neurol, Barcelona, Spain

[8] Autonomous Univ Madrid UAM, Fdn Jimenez Diaz, Dept Nephrol & Hypertens, Inst Invest Sanitaria IIS, Madrid, Spain

[9] Ctr Hosp & Univ Lisboa, Cent Hosp Curry Cabral, Dept Nephrol, Lisbon, Portugal

[10] Univ Nova Lisboa, Fac Ciencias Med Nephol, Lisbon, Portugal

[11] Med Univ Warsaw, Dept Neurol, Warsaw, Poland

[12] Med Univ Warsaw, Dept Nephrol Dialysis & Internal Med, Warsaw, Poland

[13] European Univ Cyprus, Sch Sci, Dept Hlth Sci, Nicosia, Cyprus

[14] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy

[15] Int Med Univ, UniCAMILLUS, Rome, Italy

[16] Carol Davila Univ Med & Pharm, Dr Carol Davila Teaching Hosp Nephrol, Dept Internal Med & Nephrol, Bucharest, Romania

[17] Amiens Univ, Pharmacol Dept, Med Ctr, Amiens, France

[18] Univ Picardie Jules Verne, MP3CV Mecanismes Physiopathol & Consequences Calci, EA7517, Amiens, France

[19] Univ St Cyril & Methodius, Univ Dept Nephrol, Clin Ctr Mother Theresa, Skopje, North Macedonia

[20] Renal Res Inst, New York, NY USA

[21] Assoc Ipertens Nefrol Trapianto Renale, Reggio Di Calabria, Italy

[22] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden

[23] Karolinska Univ Hosp, Karolinska Inst, CLINTEC, Renal Med, Stockholm, Sweden

[24] Ctr Hosp Setubal, Dept Nephrol, Setubal, Portugal

[25] Hacetepe Univ, Fac Med, Dept Internal Med, Div Nephrol, Ankara, Turkiye

[26] Biogem Mol Biol & Genet Res Inst, Ariano Irpino, Italy

[27] Univ Campania, Dept Translat Med Sci, Naples, Italy

[28] Med Univ Silesia, Dept Nephrol Transplantat & Internal Med, Katowice, Poland

[29] Ambroise Pare Univ Hosp, AP HP, Dept Nephrol, Boulogne Billancourt Pari, France

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2023年 / 30卷 / 09期

关键词：

chronic kidney disease; cognition; dialysis; glomerular filtration rate; vascular risk factors; GLOMERULAR-FILTRATION-RATE; RANDOMIZED CLINICAL-TRIAL; LOWERING LDL CHOLESTEROL; OLDER-ADULTS; MYOCARDIAL-INFARCTION; HYPERTENSIVE PATIENTS; PHYSICAL-EXERCISE; SUBGROUP ANALYSIS; RISK-FACTORS; OUTCOMES;

D O I：

10.1111/ene.15928

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition. Methods: Here, we review interventions for the complications of CKD (anemia, secondary hyperparathyroidism, metabolic acidosis, harmful effects of dialysis, the accumulation of uremic toxins) and for prevention of vascular events, interventions that may potentially be protective against cognitive impairment. Furthermore, we discuss nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize the latter's impact on CKD patients' daily lives. Results: A particular attention on kidney function assessment is suggested during work-up for cognitive impairment. Different approaches are promising to reduce cognitive burden in patients with CKD but the availabe dedicated data are scarce. Conclusions: There is a need for studies assessing the effect of interventions on the cognitive function of patients with CKD.

引用

页码：2899 / 2911

页数：13

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