Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment

被引：23

作者：

Pepin, Marion ^{[1
,2
,3
]}

Klimkowicz-Mrowiec, Aleksandra ^{[4
]}

Godefroy, Olivier ^{[5
,6
]}

Delgado, Pilar ^{[7
]}

Carriazo, Sol ^{[8
]}

Ferreira, Ana Carina ^{[9
,10
]}

Golenia, Aleksandra ^{[11
]}

Malyszko, Jolanta ^{[12
]}

Grodzicki, Tomasz ^{[4
]}

Giannakou, Konstantinos ^{[13
]}

Paolisso, Giuseppe ^{[14
,15
]}

Barbieri, Michelangela ^{[14
]}

Garneata, Liliana ^{[16
]}

Mocanu, Carmen Antonia ^{[16
]}

Liabeuf, Sophie ^{[17
,18
]}

Spasovski, Goce ^{[19
]}

Zoccali, Carmine ^{[20
,21
]}

Bruchfeld, Annette ^{[22
,23
]}

Farinha, Ana ^{[24
]}

Arici, Mustafa ^{[25
]}

Capasso, Giovambattista ^{[26
,27
]}

Wiecek, Andrzej A. ^{[28
]}

Massy, Ziad ^{[1
,2
,29
]}

机构：

[1] Paris Saclay Univ, Hop Paul Brousse, INSERM Inst Natl Sante & Rech Med Unit 1018, Clinical Epidemiol,CESP Ctr Epidemiol & Sante Popu, Villejuif, France

[2] Versailles St Quentin En Yvelines Univ, Villejuif, France

[3] Ambroise Pare Univ Hosp, AP HP Assistance Publ Hop Paris, Dept Geriatr, 9 Ave Charles de Gaulle, F-92100 Boulogne Billancourt Pari, France

[4] Jagiellonian Univ Med Coll, Dept Internal Med & Gerontol, Krakow, Poland

[5] Jules Verne Univ Picardie UPJV, Amiens Univ Hosp, Dept Neurol, Amiens, France

[6] Jules Verne Univ Picardie UPJV, Res Unit 4559, Lab Funct Neurosci, Amiens, France

[7] Univ Autonoma Barcelona, Vall dHebron Hosp, Dept Neurol, Barcelona, Spain

[8] Autonomous Univ Madrid UAM, Fdn Jimenez Diaz, Dept Nephrol & Hypertens, Inst Invest Sanitaria IIS, Madrid, Spain

[9] Ctr Hosp & Univ Lisboa, Cent Hosp Curry Cabral, Dept Nephrol, Lisbon, Portugal

[10] Univ Nova Lisboa, Fac Ciencias Med Nephol, Lisbon, Portugal

[11] Med Univ Warsaw, Dept Neurol, Warsaw, Poland

[12] Med Univ Warsaw, Dept Nephrol Dialysis & Internal Med, Warsaw, Poland

[13] European Univ Cyprus, Sch Sci, Dept Hlth Sci, Nicosia, Cyprus

[14] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy

[15] Int Med Univ, UniCAMILLUS, Rome, Italy

[16] Carol Davila Univ Med & Pharm, Dr Carol Davila Teaching Hosp Nephrol, Dept Internal Med & Nephrol, Bucharest, Romania

[17] Amiens Univ, Pharmacol Dept, Med Ctr, Amiens, France

[18] Univ Picardie Jules Verne, MP3CV Mecanismes Physiopathol & Consequences Calci, EA7517, Amiens, France

[19] Univ St Cyril & Methodius, Univ Dept Nephrol, Clin Ctr Mother Theresa, Skopje, North Macedonia

[20] Renal Res Inst, New York, NY USA

[21] Assoc Ipertens Nefrol Trapianto Renale, Reggio Di Calabria, Italy

[22] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden

[23] Karolinska Univ Hosp, Karolinska Inst, CLINTEC, Renal Med, Stockholm, Sweden

[24] Ctr Hosp Setubal, Dept Nephrol, Setubal, Portugal

[25] Hacetepe Univ, Fac Med, Dept Internal Med, Div Nephrol, Ankara, Turkiye

[26] Biogem Mol Biol & Genet Res Inst, Ariano Irpino, Italy

[27] Univ Campania, Dept Translat Med Sci, Naples, Italy

[28] Med Univ Silesia, Dept Nephrol Transplantat & Internal Med, Katowice, Poland

[29] Ambroise Pare Univ Hosp, AP HP, Dept Nephrol, Boulogne Billancourt Pari, France

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2023年 / 30卷 / 09期

关键词：

chronic kidney disease; cognition; dialysis; glomerular filtration rate; vascular risk factors; GLOMERULAR-FILTRATION-RATE; RANDOMIZED CLINICAL-TRIAL; LOWERING LDL CHOLESTEROL; OLDER-ADULTS; MYOCARDIAL-INFARCTION; HYPERTENSIVE PATIENTS; PHYSICAL-EXERCISE; SUBGROUP ANALYSIS; RISK-FACTORS; OUTCOMES;

D O I：

10.1111/ene.15928

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition. Methods: Here, we review interventions for the complications of CKD (anemia, secondary hyperparathyroidism, metabolic acidosis, harmful effects of dialysis, the accumulation of uremic toxins) and for prevention of vascular events, interventions that may potentially be protective against cognitive impairment. Furthermore, we discuss nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize the latter's impact on CKD patients' daily lives. Results: A particular attention on kidney function assessment is suggested during work-up for cognitive impairment. Different approaches are promising to reduce cognitive burden in patients with CKD but the availabe dedicated data are scarce. Conclusions: There is a need for studies assessing the effect of interventions on the cognitive function of patients with CKD.

引用

页码：2899 / 2911

页数：13

共 105 条

[1] Nonhematological benefits of iron
Agarwal, Rajiv
[J]. AMERICAN JOURNAL OF NEPHROLOGY, 2007, 27 (06) : 565 - 571
[2] Diabetes, Albuminuria and the Kidney-Brain Axis
Ariton, Diana Maria
Jimenez-Balado, Joan
Maisterra, Olga
Pujadas, Francesc
Soler, Maria Jose
Delgado, Pilar
[J]. JOURNAL OF CLINICAL MEDICINE, 2021, 10 (11)
[3] Baigent C, 2002, BMJ-BRIT MED J, V324, P71, DOI 10.1136/bmj.324.7329.71
[4] The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
Baigent, Colin
Landray, Martin J.
Reith, Christina
Emberson, Jonathan
Wheeler, David C.
Tomson, Charles
Wanner, Christoph
Krane, Vera
Cass, Alan
Craig, Jonathan
Neal, Bruce
Jiang, Lixin
Hooi, Lai Seong
Levin, Adeera
Agodoa, Lawrence
Gaziano, Mike
Kasiske, Bertram
Walker, Robert
Massy, Ziad A.
Feldt-Rasmussen, Bo
Krairittichai, Udom
Ophascharoensuk, Vuddidhej
Fellstrom, Bengt
Holdaas, Hallvard
Tesar, Vladimir
Wiecek, Andrzej
Grobbee, Diederick
de Zeeuw, Dick
Gronhagen-Riska, Carola
Dasgupta, Tanaji
Lewis, David
Herrington, William
Mafham, Marion
Majoni, William
Wallendszus, Karl
Grimm, Richard
Pedersen, Terje
Tobert, Jonathan
Armitage, Jane
Baxter, Alex
Bray, Christopher
Chen, Yiping
Chen, Zhengming
Hill, Michael
Knott, Carol
Parish, Sarah
Simpson, David
Sleight, Peter
Young, Alan
Collins, Rory
[J]. LANCET, 2011, 377 (9784) : 2181 - 2192
[5] Vitamin D, cognition, and dementia A systematic review and meta-analysis
Balion, Cynthia
Griffith, Lauren E.
Strifler, Lisa
Henderson, Matthew
Patterson, Christopher
Heckman, George
Llewellyn, David J.
Raina, Parminder
[J]. NEUROLOGY, 2012, 79 (13) : 1397 - 1405
[6] Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network meta-analysis
Battle, Ceri E.
Abdul-Rahim, Azmil H.
Shenkin, Susan D.
Hewitt, Jonathan
Quinn, Terry J.
[J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2021, (02):
[7] Influence of Intradialytic Aerobic Training in Cerebral Blood Flow and Cognitive Function in Patients with Chronic Kidney Disease: A Pilot Randomized Controlled Trial
Belik, Fernanda Stringuetta
Oliveira e Silva, Viviana Rugolo
Braga, Gabriel Pereira
Bazan, Rodrigo
Vogt, Barbara Perez
Teixeira Caramori, Jacqueline Costa
Barretti, Pasqual
Goncalves, Renato de Souza
Fortes Villas Boas, Paulo Jose
Hueb, Joao Carlos
Martin, Luis Cuadrado
da Silva Franco, Roberto Jorge
[J]. NEPHRON, 2018, 140 (01) : 9 - 17
[8] Cognition in chronic kidney disease: a systematic review and meta-analysis
Berger, Israel
Wu, Sunny
Masson, Philip
Kelly, Patrick J.
Duthie, Fiona A.
Whiteley, William
Parker, Daniel
Gillespie, David
Webster, Angela C.
[J]. BMC MEDICINE, 2016, 14
[9] Albuminuria as a risk factor for mild cognitive impairment and dementia-what is the evidence?
Bikbov, Boris
Jose Soler, Maria
Pesic, Vesna
Capasso, Giovambattista
Unwin, Robert
Endres, Matthias
Remuzzi, Giuseppe
Perico, Norberto
Gansevoort, Ron
Mattace-Raso, Francesco
Bruchfeld, Annette
Figurek, Andreja
Hafez, Gaye
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2022, 37 : 55 - 62
[10] Anticholinergic medication burden and cognitive function in participants of the ASPREE study
Broder, Jonathan C.
Ryan, Joanne
Shah, Raj C.
Lockery, Jessica E.
Orchard, Suzanne G.
Gilmartin-Thomas, Julia F. M.
Fravel, Michelle A.
Owen, Alice J.
Woods, Robyn L.
Wolfe, Rory
Storey, Elsdon
Murray, Anne M.
Ernst, Michael E.
[J]. PHARMACOTHERAPY, 2022, 42 (02): : 134 - 144

← 1 2 3 4 5 6 7 8 9 10 →