Pathogenesis and histological changes of nephropathy associated with COVID-19

被引:5
|
作者
Lin, Lirong [1 ]
Deng, Junhui [1 ]
Tan, Wei [1 ]
Li, Jie [2 ]
Wu, Zhifeng [1 ]
Zheng, Luquan [1 ]
Yang, Jurong [1 ]
机构
[1] Chongqing Med Univ, Affiliated Hosp 3, Gener Hosp, Dept Nephrol, Chongqing 401120, Peoples R China
[2] Yongchuan Peoples Hosp Chongqing, Dept Nephrol, Chongqing, Peoples R China
基金
中国国家自然科学基金;
关键词
COVID-19; histological; kidney injury; SARS-CoV-2; ACUTE KIDNEY INJURY; CRITICALLY-ILL PATIENTS; COLLAPSING GLOMERULOPATHY; CLINICAL CHARACTERISTICS; COMPLEMENT ACTIVATION; HOSPITALIZED-PATIENTS; DIALYSIS PATIENTS; FATAL COVID-19; DE-NOVO; DISEASE;
D O I
10.1002/jmv.28311
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Coronavirus disease 2019 (COVID-19) can cause damage to multiple organ, not only to the lungs, but also to the kidneys. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute and chronic kidney disease through direct viral infection, indirect injury, and vaccination-related injury. Like lung injury, kidney injury is also an important aspect affecting the severity and prognosis of SARS-CoV-2. This article summarizes the pathogenesis, pathological manifestations, and clinical features of SARS-CoV-2 direct or indirect renal injury. Including direct injury, indirect injury, special comorbidities (receiving kidney transplantation and chronic kidney disease), and vaccine-related renal injury, and exploring the possible therapeutic effect of anti-SARS-CoV-2 therapy on renal injury. The purpose is to provide reference for understanding COVID-19-related renal injury, guiding clinical and pathological diagnosis and treatment, and evaluating prognosis.
引用
收藏
页数:12
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