Exosomes as Carriers for Drug Delivery in Cancer Therapy

被引：23
|
作者：
Zeng, Weiping [1 ,2 ]
Wen, Zhengbo [2 ]
Chen, Honglin [2 ,3 ,4 ,5 ]
Duan, Yuyou [2 ,3 ,4 ,5 ]
机构：
[1] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China
[2] South China Univ Technol, Sch Med, Inst Life Sci, Lab Stem Cells & Translat Med, Guangzhou 510006, Peoples R China
[3] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Peoples R China
[4] South China Univ Technol, Guangdong Prov Key Lab Biomed Engn, Guangzhou 510006, Peoples R China
[5] South China Univ Technol, Key Lab Biomed Mat & Engn, Minist Educ, Guangzhou 510006, Peoples R China
来源：
PHARMACEUTICAL RESEARCH | 2023年 / 40卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Cancer therapy; Drug delivery; Extracellular vesicles; Exosomes; DENSITY-GRADIENT SEPARATION; IN-VITRO; FUNCTIONALIZED EXOSOMES; EXTRACELLULAR VESICLES; MIMETIC NANOVESICLES; TARGETED DELIVERY; MESSENGER-RNA; PACLITAXEL; BRAIN; ULTRACENTRIFUGATION;
D O I：
10.1007/s11095-022-03224-y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Exosomes are extracellular vesicles secreted by cells with a particle size of 30-150 nm in diameter. Exosomes can be used as natural drug carriers. The treatment of cancer with drug-loaded exosomes is an area of high interest. This review introduces the composition, function, isolation and characterization of exosomes, and briefly describes the selection of exosome donor cells and methods for drug loading. Through studies on therapies with drug-loaded exosomes in gastric cancer, lung cancer, brain cancer and other cancers, the advantages and disadvantages of drug-loaded exosomes have been analyzed.
引用
收藏
页码：873 / 887
页数：15
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