Phytochemical screening, biological evaluation, anatomical, and morphological investigation of Ferula tingitana L. (Apiaceae)

被引:9
作者
Karakaya, Songul [1 ]
Yuca, Hafize [2 ]
Yilmaz, Gulderen [3 ]
Aydin, Bilge [4 ]
Tekman, Enes [1 ]
Eksi, Gulnur [5 ]
Bona, Mehmet [6 ]
Goger, Gamze [7 ]
Karadayi, Mehmet [8 ]
Gulsahin, Yusuf [9 ]
Ozturk, Gozde [10 ]
Demirci, Betuel [10 ]
Guvenalp, Zuehal [2 ]
机构
[1] Ataturk Univ, Fac Pharm, Dept Pharmaceut Bot, Erzurum, Turkiye
[2] Ataturk Univ, Fac Pharm, Dept Pharmacognosy, Erzurum, Turkiye
[3] Ankara Univ, Fac Pharm, Dept Pharmaceut Bot, Ankara, Turkiye
[4] Erzincan Binali Yildirim Univ, Fac Pharm, Dept Pharmacognosy, Erzincan, Turkiye
[5] Medipol Univ, Fac Pharm, Dept Pharmacognosy, Istanbul, Turkiye
[6] Istanbul Univ, Fac Sci, Dept Biol, Istanbul, Turkiye
[7] Afyokarahisar Hlth Sci Univ, Fac Pharm, Dept Pharmacognosy, Afyon, Turkiye
[8] Ataturk Univ, Fac Sci, Dept Biol, Erzurum, Turkiye
[9] Ataturk Univ, Inst Nat & Appl Sci, Erzurum, Turkiye
[10] Anadolu Univ, Fac Pharm, Dept Pharmacognosy, Eskisehir, Turkiye
关键词
Ferula tingitana; Antioxidant; Anticholinesterase; Antidiabetic; Anatomical; Morphological; ESSENTIAL OIL; CHEMICAL-COMPOSITION; SODIUM-AZIDE; GENUS-FERULA; ANTIOXIDANT; EXTRACTS; INHIBITORS; CYANIDIN-3-RUTINOSIDE; PHARMACOLOGY;
D O I
10.1007/s00709-023-01874-2
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Ferula tingitana L. is a high perennial plant and its leaf is an alternate arrangement and yellow, and its flowers are unisexual like other Apiaceae. It has been used as a spice and for various medicinal purposes in the Mediterranean region. The paper reports antidiabetic, antimicrobial, anticholinesterase, antioxidant, and genotoxic activities of leaves, flowers, stems, and fruits methanol extracts of F. tingitana. Also, quantitative determination of some secondary metabolites was also analyzed by LC-MS/MS. Moreover, chemical composition of essential oils was analyzed. Consequently, anatomical, and morphological properties of plant were investigated. Germacrene D (23.6%), 1,3,5-trimethylbenzene (18.4%), and alpha-pinene (50.0%) were found as the main compounds in flower, leaf, and stem oils, respectively. The cortex in stem, pedicel, and fruit is characterized by angular collenchyma cells and a distinct cambium layer. 6 compounds (quinic acid, fumaric acid, keracyanin chloride, cyanidin-3-O-glucoside, chlorogenic acid, hesperidin) were observed in samples. Leaf extract showed anticholinesterase activity. Leaf and flower extracts showed the highest % inhibition value on ABTS(center dot+) and DPPH center dot. Leaf extract has the strongest antioxidant effect because it is rich in total phenolic contents. All extracts of F. tingitana were found generally effective against C. albicans. Stem extract was found effective against E. coli and flower extract was found more effective against S. enterica and C. albicans. Bacterial genotoxicity results showed that extracts did not have genotoxic activity on tester strains S. typhimurium and E. coli WP2uvrA. Thus, it revealed that extracts were genotoxic-ally safe at applied concentrations up to 3 mg/plate.
引用
收藏
页码:1581 / 1601
页数:21
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