Intra-Arterial Chemotherapy for Retinoblastoma

被引：1

作者：

Muns, Sofia M. ^{[1
]}

Villegas, Victor M. ^{[1
,2
,3
]}

Ramos-Acevedo, Juan ^{[4
]}

Murray, Timothy G. ^{[5
]}

Soto-Velez, Leslie A. ^{[6
]}

Echevarria-Escudero, Maria ^{[6
]}

Colon-Gonzalez, Gloria ^{[6
]}

Guerra, Jhon ^{[6
]}

Garcia, Ruth Padilla ^{[7
]}

机构：

[1] Univ Puerto Rico, Dept Ophthalmol, Med Sci Campus,POB 365067, San Juan, PR 00936 USA

[2] Univ Miami, Bascom Palmer Eye Inst, Dept Ophthalmol, Miller Sch Med, Miami, FL 33136 USA

[3] Ponce Hlth Sci Univ, Dept Surg, Ponce, PR 00716 USA

[4] HIMA San Pablo Hosp, Neurosurg Dept, Caguas, PR USA

[5] Murray Ocular Oncol & Retina, Miami, FL USA

[6] Univ Puerto Rico, Dept Pediat Hematol Oncol, San Juan, PR USA

[7] HIMA San Pablo Hosp, Dept Anesthesiol, Caguas, PR USA

来源：

CURRENT OPHTHALMOLOGY REPORTS | 2023年 / 11卷 / 2期

关键词：

Intra-arterial chemotherapy; Retinoblastoma; Ocular oncology; Retina; Digitally subtracted selective arteriogram; INTERNATIONAL-CLASSIFICATION; INTRAVENOUS CHEMOTHERAPY; OUTCOMES;

D O I：

10.1007/s40135-023-00311-0

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose of ReviewTo review the surgical technique, pharmacotherapy, contraindications, and outcomes of intra-arterial chemotherapy (IAC) in the treatment of retinoblastoma.Recent FindingsIAC has emerged as a therapy for retinoblastoma. During IAC, a catheter is placed in the ophthalmic artery to selectively deliver chemotherapy. No universal protocol exists for the treatment of retinoblastoma, but melphalan, carboplatin, and topotecan triple-drug regimen are commonly used in IAC. The IAC doses are based on the patients' age and weight and the severity and extent of the disease. Contraindications for IAC are poor visualization of the retinoblastoma tumor or extraocular extension.IAC is a safe and effective treatment for retinoblastoma. Group B and C eyes have excellent outcomes of eye salvage. Eye salvage in groups D and E eyes is better with IAC than with systemic intravenous chemotherapy. However, randomized controlled trials are needed to further assess outcomes of IAC for retinoblastoma.

引用

页码：34 / 39

页数：6

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