Assessment of a Non-Invasive Brain Pulse Monitor to Measure Intra-Cranial Pressure Following Acute Brain Injury

被引：11

作者：

Dixon, Barry ^{[1
,2
,3
,7
]}

Sharkey, Jessica M. ^{[1
]}

Teo, Elliot J. ^{[1
,2
]}

Grace, Sally A. ^{[1
]}

Savage, Jacqui S. ^{[1
]}

Udy, Andrew ^{[4
]}

Smith, Paul ^{[5
,6
]}

Hellerstedt, Jack ^{[1
]}

Santamaria, John D. ^{[2
]}

机构：

[1] Cyban Pty Ltd, Melbourne, Vic, Australia

[2] St Vincents Hosp, Dept Crit Care Med, Melbourne, Australia

[3] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

[4] Alfred Hosp, Dept Crit Care Med, Melbourne, Australia

[5] St Vincents Hosp, Dept Neurosurg, Melbourne, Australia

[6] Univ Melbourne, Med Sch, Melbourne, Vic, Australia

[7] St Vincents Hosp Melbourne, Dept Crit Care Med, 41 Victoria Parade, Fitzroy, Vic 3065, Australia

来源：

MEDICAL DEVICES-EVIDENCE AND RESEARCH | 2023年 / 16卷

关键词：

intracranial pressure; acute brain injury; monitoring; non-invasive; photoplethysmography; TISSUE OXYGEN; FLUID PRESSURE; BLOOD-FLOW; HYPERTENSION; PREDICTION; COMPONENTS; MORTALITY; OXIMETER; WAVEFORM; SENSORS;

D O I：

10.2147/MDER.S398193

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Background: Intracranial pressure (ICP) monitoring requires placing a hole in the skull through which an invasive pressure monitor is inserted into the brain. This approach has risks for the patient and is expensive. We have developed a non-invasive brain pulse monitor that uses red light to detect a photoplethysmographic (PPG) signal arising from the blood vessels on the brain's cortical surface. The brain PPG and the invasive ICP waveform share morphological features which may allow measurement of the intracranial pressure. Methods: We enrolled critically ill patients with an acute brain injury with invasive ICP monitoring to assess the new monitor. A total of 24 simultaneous invasive ICP and brain pulse monitor PPG measurements were undertaken in 12 patients over a range of ICP levels. Results: The waveform morphologies were similar for the invasive ICP and brain pulse monitor PPG approach. Both methods demonstrated a progressive increase in the amplitude of P2 relative to P1 with increasing ICP levels. An automated algorithm was developed to assess the PPG morphological features in relation to the ICP level. A correlation was demonstrated between the brain pulse waveform morphology and ICP levels, R2=0.66, P < 0.001. Conclusion: The brain pulse monitor's PPG waveform demonstrated morphological features were similar to the invasive ICP waveform over a range of ICP levels, these features may provide a method to measure ICP levels.

引用

页码：15 / 26

页数：12

共 63 条

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