The Impact of microRNA SNPS on Breast Cancer: Potential Biomarkers for Disease Detection

被引：2

作者：

Chauhan, Sakshi ^{[1
]}

Mathur, Runjhun ^{[1
,2
]}

Jha, Abhimanyu Kumar ^{[1
]}

机构：

[1] Sharda Univ, Greater Noida, Uttar Pradesh, India

[2] Dr APJ Abdul Kalam Tech Univ, Lucknow, Uttar Pradesh, India

来源：

MOLECULAR BIOTECHNOLOGY | 2025年 / 67卷 / 03期

关键词：

Single Nucleotides Polymorphism; microRNAs; Breast Cancer; Susceptibility; Biomarkers; Therapeutics; BINDING-SITE; GENETIC-VARIANTS; TARGET SITE; RISK; POLYMORPHISMS; ASSOCIATION; STATISTICS; MUTATIONS; THERAPY;

D O I：

10.1007/s12033-024-01113-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is considered a significant health concern worldwide, with genetic predisposition playing a critical role in its etiology. Single nucleotide polymorphisms (SNPs), particularly those within the 3' untranslated regions (3'UTRs) of target genes, are emerging as key factors in breast cancer susceptibility. Specifically, miRNAs have been recognized as possible novel approach for biomarkers discovery for both prognosis and diagnosis due to their direct association with cancer progression. Regional disparities in breast cancer incidence underscore the need for precise interventions, considering socio-cultural and economic factors. This review explores into the differential effects of SNP-miRNA interactions on breast cancer risk, emphasizing both risk-enhancing and protective associations across diverse populations. Furthermore, it explores the clinical implications of these findings, highlighting the potential of personalized approaches in breast cancer management. Additionally, it reviews the evolving therapeutic prospect of microRNAs (miRNAs), extending beyond cancer therapeutics to encompass various diseases, indicative of their versatility as therapeutic agents.

引用

页码：845 / 861

页数：17

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