Metabolic reprogramming in the tumor microenvironment of liver cancer

被引：63

作者：

Lin, Jian ^{[1
,4
]}

Rao, Dongning ^{[2
]}

Zhang, Mao ^{[2
]}

Gao, Qiang ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Jinshan Hosp, Ctr Tumor Diag & Therapy, Shanghai, Peoples R China

[2] Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat,Key Lab Carcinogene, Shanghai 200032, Peoples R China

[3] Fudan Univ, Inst Biomed Sci, Key Lab Med Epigenet & Metab, Shanghai 200032, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Zhejiang Prov Key Lab Pancreat Dis, Hangzhou, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2024年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Liver cancer; Metabolic reprogramming; Immune microenvironment; Gut-liver axis; T-CELL METABOLISM; HEPATOCELLULAR-CARCINOMA; LACTIC-ACID; PROTEOGENOMIC CHARACTERIZATION; GLUCOSE TRANSPORTERS; ENHANCES SURVIVAL; SUPPRESSOR-CELLS; GUT MICROBIOME; DOUBLE-BLIND; PHASE-I;

D O I：

10.1186/s13045-024-01527-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. In addition to supporting continuous tumor growth and survival, disrupted metabolic process also creates obstacles for the anticancer immune response and restrains durable clinical remission following immunotherapy. In this review, we elucidate the metabolic communication between liver cancer cells and their surrounding immune cells and discuss how metabolic reprogramming of liver cancer impacts the immune microenvironment and the efficacy of anticancer immunotherapy. We also describe the crucial role of the gut-liver axis in remodeling the metabolic crosstalk of immune surveillance and escape, highlighting novel therapeutic opportunities.

引用

页数：19

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