The benefits of clustering in TNF receptor superfamily signaling

被引：23

作者：

Vanamee, Eva S. ^{[1
]}

Faustman, Denise L. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Immunobiol Dept, Boston, MA 02114 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

TNF receptor superfamily (TNFRSF); TNF signaling; receptor clustering; TNFR agonism and antagonism; signal amplification; CRYSTAL-STRUCTURE; TRAIL; BTLA; DIMERIZATION; APOPTOSIS; TRIMERS; DOMAIN; HVEM; OLIGOMERIZATION; PROTEINS;

D O I：

10.3389/fimmu.2023.1225704

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. This review paper synthesizes key findings from recent studies, highlighting the importance of clustering in TNF receptor superfamily signaling. We discuss the underlying molecular mechanisms of signaling, the functional consequences of receptor clustering, and potential therapeutic implications of targeting surface structures of receptor complexes.

引用

页数：11

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