A 19-Year-Old Adolescent with Probable Alzheimer's Disease

被引：22

作者：

Jia, Jianping ^{[1
,2
,3
,4
,5
,6
]}

Zhang, Yue ^{[1
,2
]}

Shi, Yuqing ^{[1
,2
]}

Yin, Xuping ^{[1
,2
]}

Wang, Shiyuan ^{[1
,2
]}

Li, Yan ^{[1
,2
]}

Zhao, Tan ^{[1
,2
]}

Liu, Wenying ^{[1
,2
]}

Zhou, Aihong ^{[1
,2
]}

Jia, Longfei ^{[1
,2
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Innovat Ctr Neurol Disorders, Beijing, Peoples R China

[2] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Dept Neurol, Changchun St 45, Beijing 100053, Peoples R China

[3] Beijing Key Lab Geriatr Cognit Disorders, Beijing, Peoples R China

[4] Capital Med Univ, Clin Ctr Neurodegenerat Dis & Memory Impairment, Beijing, Peoples R China

[5] Capital Med Univ, Ctr Alzheimers Dis, Collaborat Innovat Ctr Brain Disorders, Beijing Inst Brain Disorders, Beijing, Peoples R China

[6] Minist Educ, Key Lab Neurodegenerat Dis, Beijing, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2023年 / 91卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Case report; early-onset Alzheimer's disease; gene mutation; hippocampal atrophy; memory impairment; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; PET; RECOMMENDATIONS; FLORBETAPIR; MUTATION; AUTOPSY; PLAQUES;

D O I：

10.3233/JAD-221065

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) primarily affects older adults. In this report, we present the case of a 19-year-old male with gradual memory decline for 2 years and World Health Organization-University of California Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) results also showing memory impairment. Positron emission tomography-magnetic resonance imaging with 18F fluorodeoxyglucose revealed atrophy of the bilateral hippocampus and hypometabolism in the bilateral temporal lobe. Examination of the patient's cerebrospinal fluid showed an increased concentration of p-tau181 and a decreased amyloid-beta 42/40 ratio. However, through whole-genome sequencing, no known gene mutations were identified. Considering the above, the patient was diagnosed with probable AD.

引用

页码：915 / 922

页数：8

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