1,4-Dihydropyridine Derivatives: An Overview of Synthesis Conditions and Biological Tests

被引：2

作者：

Lago, Aline de Fatima Silva ^{[1
]}

de Benedicto, Danilo Forti Carvalho ^{[1
]}

da Silva, Larissa ^{[1
]}

Thomasi, Sergio Scherrer ^{[1
]}

机构：

[1] Univ Fed Lavras, Inst Nat Sci, Dept Chem, BR-37200900 Lavras, MG, Brazil

来源：

CURRENT ORGANIC CHEMISTRY | 2023年 / 27卷 / 18期

关键词：

1,4-dihydropyridine; one-pot synthesis; biological activities; experimental conditions; catalyst; hexahydroacredinedione; hexahydroquinoline; benzoacridinone; ONE-POT SYNTHESIS; SOLVENT-FREE SYNTHESIS; UNSYMMETRICAL HANTZSCH REACTION; PERIODIC MESOPOROUS ORGANOSILICA; MICROWAVE-ASSISTED SYNTHESIS; IONIC-LIQUID; MULTICOMPONENT SYNTHESIS; HIGHLY EFFICIENT; HETEROGENEOUS CATALYST; GREEN SYNTHESIS;

D O I：

10.2174/0113852728264228231013074432

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,4-dihydropyridine is a versatile class of compounds with multiple biological activities, thus holding significant pharmacological potential. Recent studies have provided evidence concerning the anticancer, antimicrobial, and anti-inflammatory properties of 1,4-dihydropyridines, as well as their potential in Alzheimer's disease treatment. Therefore, this class of compounds is a promising candidate in studies of drug development and drug discovery. The major derivatives of 1,4-dihydropyridine can be synthesized through one-pot synthesis in many different ways, varying the solvents, catalysts, and experimental conditions. Due to the compound's remarkable potential and ease of production, in this review we aimed to present the biological activities and synthesis methodologies of the main 1,4-dihydropyridine derivatives reported by scientific literature over the past decade.

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页码：1567 / 1610

页数：44

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