1,4-Dihydropyridine Derivatives: An Overview of Synthesis Conditions and Biological Tests

被引:2
作者
Lago, Aline de Fatima Silva [1 ]
de Benedicto, Danilo Forti Carvalho [1 ]
da Silva, Larissa [1 ]
Thomasi, Sergio Scherrer [1 ]
机构
[1] Univ Fed Lavras, Inst Nat Sci, Dept Chem, BR-37200900 Lavras, MG, Brazil
关键词
1,4-dihydropyridine; one-pot synthesis; biological activities; experimental conditions; catalyst; hexahydroacredinedione; hexahydroquinoline; benzoacridinone; ONE-POT SYNTHESIS; SOLVENT-FREE SYNTHESIS; UNSYMMETRICAL HANTZSCH REACTION; PERIODIC MESOPOROUS ORGANOSILICA; MICROWAVE-ASSISTED SYNTHESIS; IONIC-LIQUID; MULTICOMPONENT SYNTHESIS; HIGHLY EFFICIENT; HETEROGENEOUS CATALYST; GREEN SYNTHESIS;
D O I
10.2174/0113852728264228231013074432
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
1,4-dihydropyridine is a versatile class of compounds with multiple biological activities, thus holding significant pharmacological potential. Recent studies have provided evidence concerning the anticancer, antimicrobial, and anti-inflammatory properties of 1,4-dihydropyridines, as well as their potential in Alzheimer's disease treatment. Therefore, this class of compounds is a promising candidate in studies of drug development and drug discovery. The major derivatives of 1,4-dihydropyridine can be synthesized through one-pot synthesis in many different ways, varying the solvents, catalysts, and experimental conditions. Due to the compound's remarkable potential and ease of production, in this review we aimed to present the biological activities and synthesis methodologies of the main 1,4-dihydropyridine derivatives reported by scientific literature over the past decade.
引用
收藏
页码:1567 / 1610
页数:44
相关论文
共 290 条
[1]  
Abd-Allah O.A., 2015, Med. Chem, V2, P2161
[2]   Facile and efficient synthesis of acridinediones from primary amino alcohols via three-component condensation reactions assisted by microwave irradiation [J].
Abdelhamid, Antar A. ;
Mohamed, S. K. ;
Maharramov, A. M. ;
Khalilov, A. N. ;
Allahverdiev, M. A. .
JOURNAL OF SAUDI CHEMICAL SOCIETY, 2014, 18 (05) :474-478
[3]   MCM-41 Functionalized with B-F Bond: Preparation, Characterization and Catalytic Application in the Synthesis of Polyhydroquinolines [J].
Abdollahi-Alibeik, Mohammad ;
Rezaeipoor-Anari, Ali .
LETTERS IN ORGANIC CHEMISTRY, 2015, 12 (09) :651-658
[4]   TiO2 Nanoparticles as an Efficient Catalyst for the One-pot Preparation of Tetrahydrobenzo[c]acridines in Aqueous Media [J].
Abdolmohammadi, Shahrzad ;
Mohammadnejad, Mandieh ;
Shafaei, Faezeh .
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2013, 68 (04) :362-366
[5]   Graphene Oxide as Highly Effective and Readily Recyclable Catalyst Using for the One-Pot Synthesis of 1,8-Dioxoacridine Derivatives [J].
Aday, Burak ;
Pamuk, Handan ;
Kaya, Muharrem ;
Sen, Fatih .
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2016, 16 (06) :6498-6504
[6]   One-pot, efficient and green synthesis of acridinedione derivatives using highly monodisperse platinum nanoparticles supported with reduced graphene oxide [J].
Aday, Burak ;
Yildiz, Yunus ;
Ulus, Ramazan ;
Eris, Sinan ;
Sen, Fatih ;
Kaya, Muharrem .
NEW JOURNAL OF CHEMISTRY, 2016, 40 (01) :748-754
[7]   A new In-SiO2 composite catalyst in the solvent-free multicomponent synthesis of Ca2+ channel blockers nifedipine and nemadipine B [J].
Affeldt, Ricardo F. ;
Benvenutti, Edilson V. ;
Russowsky, Dennis .
NEW JOURNAL OF CHEMISTRY, 2012, 36 (07) :1502-1511
[8]   One-pot synthesis of 1,4-dihydropyridines andN-arylquinolines in the presence of copper complex stabilized on MnFe2O4(MFO) as a novel organic-inorganic hybrid material and magnetically retrievable catalyst [J].
Ahadi, Najmieh ;
Mobinikhaledi, Akbar ;
Bodaghifard, Mohammad Ali .
APPLIED ORGANOMETALLIC CHEMISTRY, 2020, 34 (10)
[9]   Synthetic Diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates Induce Apoptosis [J].
Ahn, Seunghyun ;
Lee, Youngshim ;
Park, Jihyun ;
Lee, Junho ;
Shin, Soon Y. ;
Lee, Young H. ;
Koh, Dongsoo ;
Lim, Yoongho .
MEDICINAL CHEMISTRY, 2018, 14 (08) :851-862
[10]   One-pot synthesis of 2-amino-3-cyanopyridines and hexahydroquinolines using eggshell-based nano-magnetic solid acid catalyst via anomeric-based oxidation [J].
Akbarpoor, Tahere ;
Khazaei, Ardeshir ;
Seyf, Jaber Yousefi ;
Sarmasti, Negin ;
Gilan, Maryam Mahmoudiani .
RESEARCH ON CHEMICAL INTERMEDIATES, 2020, 46 (02) :1539-1554