How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation

被引：1
|
作者：
Jiang, Shan [1 ]
Yan, Han [1 ]
Lu, Xuan [1 ]
Wei, Ruowen [1 ]
Chen, Haoran [1 ]
Zhang, Ao [1 ]
Shi, Wei [1 ]
Xia, Linghui [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
acute myeloid leukaemia (AML); elderly patients; allogeneic hematopoietic cell transplantation; conditioning regimen; GvHD; relapse; VERSUS-HOST-DISEASE; COMPREHENSIVE GERIATRIC ASSESSMENT; RECEIVING INDUCTION CHEMOTHERAPY; HUMAN HERPESVIRUS-6 ENCEPHALITIS; ACUTE MYELOGENOUS LEUKEMIA; DONOR LYMPHOCYTE INFUSION; INVASIVE FUNGAL DISEASES; LONG-TERM SURVIVORS; RISK ACUTE-LEUKEMIA; OLDER-ADULTS;
D O I：
10.3389/fimmu.2023.1102966
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In recent years, with the gradual advancement of haploidentical transplantation technology, the availability of donors has increased significantly, along with the widespread use of reduced-intensity conditioning and the improvement of nursing techniques, giving more elderly acute myeloid leukemia (AML) patients the chance to receive allogeneic hematopoietic stem cell transplantation. We have summarized the classic and recently proposed pre-transplant assessment methods and assessed the various sources of donors, conditioning regimens, and post-transplant complication management based on the outcomes of large-scale clinical studies for elderly AML patients.
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页数：14
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