Ferroptosis: From Basic Research to Clinical Therapeutics in Hepatocellular Carcinoma

被引：26
作者：
Huang, Ziyue [1 ]
Xia, Haoming [1 ]
Cui, Yunfu [1 ]
Yam, Judy Wai Ping [2 ]
Xu, Yi [1 ,2 ,3 ]
机构：
[1] Harbin Med Univ, Dept Hepatopancreatobiliary Surg, Affiliated Hosp 2, 246 Xuefu Rd, Harbin 150086, Heilongjiang, Peoples R China
[2] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pathol, Hong Kong, Peoples R China
[3] Harbin Med Univ, Key Lab Myocardial Ischem, Minist Educ, Harbin, Heilongjiang, Peoples R China
来源：
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2023年 / 11卷 / 01期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Hepatocellular carcinoma; Ferroptosis; Sorafenib; Cancer therapy; Molecular targets; TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; CELL-DEATH; REGULATES FERROPTOSIS; LIPID-PEROXIDATION; OXIDATIVE STRESS; SORAFENIB; CANCER; LIVER; SUPPRESSION; SENSITIVITY;
D O I：
10.14218/JCTH.2022.00255
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatocellular carcinoma (HCC) is one of the most common and highly heterogeneous malignancies worldwide. Despite the rapid development of multidisciplinary treatment and personalized precision medicine strategies, the overall survival of HCC patients remains poor. The limited survival benefit may be attributed to difficulty in early diagnosis, the high recurrence rate and high tumor heterogeneity. Ferroptosis, a novel mode of cell death driven by iron-dependent lipid peroxidation, has been implicated in the development and therapeutic response of various tumors, including HCC. In this review, we discuss the regulatory network of ferroptosis, describe the crosstalk between ferroptosis and HCC-related signaling pathways, and elucidate the potential role of ferroptosis in various treatment modalities for HCC, such as systemic therapy, radiotherapy, immunotherapy, interventional therapy and nanotherapy, and applications in the diagnosis and prognosis of HCC, to provide a theoretical basis for the diagnosis and treatment of HCC to effectively improve the survival of HCC patients.
引用
收藏
页码：207 / 218
页数：12
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