Facile access to 2-amino-4-aryl-5H-chromeno[4,3-b]pyridine-3-carbonitriles through a strategy of one-pot Michael/cyclization reaction

被引：3

作者：

Wang, Dao-Cai ^{[1
,2
]}

Chen, Xi-Xia ^{[1
]}

Liu, Xiao-Peng ^{[1
,2
]}

机构：

[1] Hubei Minzu Univ, Coll Biol & Food Engn, Enshi, Peoples R China

[2] Hubei Minzu Univ, Coll Biol & Food Engn, Enshi 445000, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 09期

关键词：

FRUITING BODIES; ALKALOIDS; DERIVATIVES; ANNULATION; DESIGN;

D O I：

10.1002/jhet.4704

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented cascade Michael/cyclization reaction of 4-chromanone derivatives, aldehydes, and 2-cyanothioacetamide was presented for the preparation of distinctive 2-amino-4-aryl-5H-chromeno[4,3-b]pyridine-3-carbonitriles promoted by ammonium acetate. The optimized reaction conditions were used for the synthesis of 2-amino-4-aryl-5H-chromeno[4,3-b]pyridine-3-carbonitrile derivatives in medium to high yields. The synthetic method features a convenient operational process, easy access to raw material as well as high atom economy.

引用

页码：1582 / 1592

页数：11

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