Sotrovimab Resistance and Viral Persistence After Treatment of Immunocompromised Patients Infected With the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant

被引：31

作者：

Huygens, Sammy ^{[1
,2
]}

Munnink, Bas Oude ^{[3
]}

Gharbharan, Arvind ^{[1
,2
]}

Koopmans, Marion ^{[3
]}

Rijnders, Bart ^{[1
,2
]}

机构：

[1] Erasmus MC, Univ Med Ctr, Dept Internal Med, Sect Infect Dis, Rotterdam, Netherlands

[2] Erasmus MC, Univ Med Ctr, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands

[3] Erasmus MC, Univ Med Ctr, Dept Virosci, Rotterdam, Netherlands

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 03期

关键词：

SARS-CoV-2; Omicron; sotrovimab; resistance; immunocompromised;

D O I：

10.1093/cid/ciac601

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viral evolution was evaluated in 47 immunocompromised patients treated with sotrovimab. Sequencing of SARS-CoV-2 following therapy was successful in 16. Mutations associated with sotrovimab resistance were documented in 6; viral replication continued after 30 days in 5. Combination antibody therapy may be required to avoid acquired resistance in immunocompromised patients.

引用

页码：E507 / E509

页数：3

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