COVID-19 related neurological manifestations in Parkinson's disease: has ferroptosis been a suspect?

被引：4

作者：

Jia, Fengju ^{[1
]}

Han, Jing ^{[1
]}

机构：

[1] Qingdao Univ, Sch Nursing, 308 Ningxia Rd, Qingdao 266071, Peoples R China

来源：

CELL DEATH DISCOVERY | 2024年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ALPHA-SYNUCLEIN; UP-REGULATION; CELL-DEATH; SARS-COV-2; PROTEIN; MODEL; SPIKE; ACTIVATION; INFECTION; DEFICITS;

D O I：

10.1038/s41420-024-01915-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A rising number of patient cases point to a probable link between SARS-CoV-2 infection and Parkinson's disease (PD), yet the mechanisms by which SARS-CoV-2 affects the brain and generates neuropsychiatric symptoms in COVID-19 patients remain unknown. Ferroptosis, a distinct iron-dependent non-apoptotic type of cell death characterized by lipid peroxidation and glutathione depletion, a key factor in neurological disorders. Ferroptosis may have a pathogenic role in COVID-19, according to recent findings, however its potential contributions to COVID-19-related PD have not yet been investigated. This review covers potential paths for SARS-CoV-2 infection of the brain. Among these putative processes, ferroptosis may contribute to the etiology of COVID-19-associated PD, potentially providing therapeutic methods.

引用

页数：7

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