The role of glycogen synthase kinase 3 beta in neurodegenerative diseases

被引：16
作者：
Yu, Honglu [1 ]
Xiong, Min [1 ]
Zhang, Zhentao [1 ,2 ]
机构：
[1] Wuhan Univ, Dept Neurol, Renmin Hosp, Wuhan, Peoples R China
[2] Wuhan Univ, TaiKang Ctr Life & Med Sci, Wuhan, Peoples R China
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2023年 / 16卷
基金：
中国国家自然科学基金;
关键词：
protein aggregation; Alzheimer's disease; Parkinson's disease; Huntington's disease; amyotrophic lateral sclerosis; MOUSE MODELS; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; TAU PHOSPHORYLATION; MUTANT HUNTINGTIN; SPINAL-CORD; INHIBITION; LITHIUM;
D O I：
10.3389/fnmol.2023.1209703
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and so on. They are characterized by progressive loss or dysfunction of neurons in the central or peripheral nervous system and share several cellular and molecular mechanisms, including protein aggregation, mitochondrial dysfunction, gene mutations, and chronic neuroinflammation. Glycogen synthase kinase-3 beta (GSK-3 & beta;) is a serine/threonine kinase that is believed to play a pivotal role in the pathogenesis of NDDs. Here we summarize the structure and physiological functions of GSK3 & beta; and explore its involvement in NDDs. We also discussed its potential as a therapeutic target.
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页数：10
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