Toxicity and Mechanisms of Engineered Nanoparticles in Animals with Established Allergic Asthma

被引:8
作者
Deng, Rui [1 ,4 ]
Zhu, Ya [2 ]
Wu, Xinyue [3 ]
Wang, Mingpu [1 ]
机构
[1] Chongqing Univ, Sch Civil Engn, Joint Int Res Lab Green Bldg & Built Environm, Minist Educ, Chongqing 400045, Peoples R China
[2] Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou 325035, Peoples R China
[3] Zhejiang Univ, Dept Environm Sci, Zhejiang Prov Key Lab Organ Pollut Proc & Control, Hangzhou 310058, Peoples R China
[4] Chongqing Univ, Sch Civil Engn, Chongqing 400045, Peoples R China
来源
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2023年 / 18卷
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
engineered nanoparticles; allergic asthma; mouse model; toxicity; mechanisms; adjuvant effect; MULTIWALLED CARBON NANOTUBES; AIRWAY INFLAMMATION; MURINE MODEL; SILVER NANOPARTICLES; IMMUNE-RESPONSES; EMERGING TRENDS; EXPOSURE; HYPERRESPONSIVENESS; EXACERBATION; TOXICOLOGY;
D O I
10.2147/IJN.S411804
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Asthma is a chronic respiratory disease that is highly sensitive to environmental pollutants, including engineered nanoparticles (NPs). Exposure to NPs has become a growing concern for human health, especially for susceptible populations. Toxicological studies have demonstrated strong associations between ubiquitous NPs and allergic asthma. In this review, we analyze articles that focus on adverse health effects induced by NPs in animal models of allergic asthma to highlight their critical role in asthma. We also integrate potential mechanisms that could stimulate and aggravate asthma by NPs. The toxic effects of NPs are influenced by their physicochemical properties, exposure dose, duration, route, as well as the exposure order between NPs and allergens. The toxic mechanisms involve oxidative stress, various inflammasomes, antigen presenting cells, immune cells, and signaling pathways. We suggest that future research should concentrate on establishing standardized models, exploring mechanistic insights at the molecular level, assessing the combined effects of binary exposures, and determining safe exposure levels of NPs. This work provides concrete evidence of the hazards posed by NPs in animals with compromised respiratory health and supports the modifying role of NPs exposure in allergic asthma.
引用
收藏
页码:3489 / 3508
页数:20
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