Air Pollution and Lung Cancer: Contributions of Extracellular Vesicles as Pathogenic Mechanisms and Clinical Utility

被引：4

作者：

Gonzalez-Ruiz, Jonathan ^{[1
]}

Baccarelli, Andrea A. ^{[2
]}

Cantu-de-Leon, David ^{[1
]}

Prada, Diddier ^{[3
,4
]}

机构：

[1] Inst Nacl Cancerol, Mexico City 14080, Mexico

[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY 10032 USA

[3] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, 1 Gustave L Levy Pl 212 241-6500,Room L2-38, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, Inst Hlth Equ Res, 1 Gustave L Levy Pl 212 241-6500,Room L2-38, New York, NY 10029 USA

来源：

CURRENT ENVIRONMENTAL HEALTH REPORTS | 2023年 / 10卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Air pollution; Lung cancer; Extracellular vesicles; Biomarkers; Therapeutic targets; POLYCYCLIC AROMATIC-HYDROCARBONS; DNA-DAMAGE; INFLAMMATION; CELLS; CARCINOGENESIS; MACROPHAGE; COMMUNICATION; MICROVESICLES; BIOMARKERS; MEDIATORS;

D O I：

10.1007/s40572-023-00421-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Purpose of ReviewThis review addresses the pressing issue of air pollution's threat to human health, focusing on its connection to non-small cell lung cancer (NSCLC) development. The aim is to explore the role of extracellular vesicles (EVs) as potential pathogenic mechanisms in lung cancer, including NSCLC, induced by air pollutants.Recent FindingsRecent research highlights EVs as vital mediators of intercellular communication and key contributors to cancer progression. Notably, this review emphasizes the cargo of EVs released by both cancerous and non-cancerous lung cells, shedding light on their potential role in promoting various aspects of tumor development.SummaryThe review underscores the importance of comprehending the intricate interplay between air pollution, biological damage mechanisms, and EV-mediated communication during NSCLC development. Major takeaways emphasize the significance of this understanding in addressing air pollution-related lung cancer. Future research avenues are also highlighted, aiming to enhance the applicability of EVs for diagnosis and targeted therapies, ultimately mitigating the inevitable impact of air pollution on NSCLC development and treatment.

引用

页码：478 / 489

页数：12