Sphingolipid metabolism in brain insulin resistance and neurological diseases

被引：21

作者：

Mei, Meng ^{[1
]}

Liu, Maochang ^{[1
]}

Mei, Yan ^{[1
]}

Zhao, Jing ^{[2
]}

Li, Yang ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Tongji Med Coll,Dept Pharm, Wuhan, Peoples R China

[2] Beijing Univ Chinese Med, Adm Off, Beijing, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷

关键词：

sphingolipid metabolism; brain insulin resistance; ceramide; sphingosine-1-phosphate; Alzheimer's disease; Parkinson's disease; SPHINGOMYELIN SYNTHASE 2; CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; SPHINGOSINE; 1-PHOSPHATE; PLASMA-MEMBRANE; SERINE PALMITOYLTRANSFERASE; GLUCOSYLCERAMIDE SYNTHASE; INTRANASAL INSULIN; GLUCOSE-METABOLISM;

D O I：

10.3389/fendo.2023.1243132

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sphingolipids, as members of the large lipid family, are important components of plasma membrane. Sphingolipids participate in biological signal transduction to regulate various important physiological processes such as cell growth, apoptosis, senescence, and differentiation. Numerous studies have demonstrated that sphingolipids are strongly associated with glucose metabolism and insulin resistance. Insulin resistance, including peripheral insulin resistance and brain insulin resistance, is closely related to the occurrence and development of many metabolic diseases. In addition to metabolic diseases, like type 2 diabetes, brain insulin resistance is also involved in the progression of neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. However, the specific mechanism of sphingolipids in brain insulin resistance has not been systematically summarized. This article reviews the involvement of sphingolipids in brain insulin resistance, highlighting the role and molecular biological mechanism of sphingolipid metabolism in cognitive dysfunctions and neuropathological abnormalities of the brain.

引用

页数：15

共 151 条

[51] Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage [J].