Interim FDG-PET/CT for Response Assessment of Lymphoma

被引:12
作者
Zeman, Merissa N. [1 ]
Akin, Esma A. [2 ,3 ]
Merryman, Reid W. [4 ]
Jacene, Heather A. [1 ,5 ,6 ]
机构
[1] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02215 USA
[2] Harvard Med Sch, Boston, MA USA
[3] George Washington Univ, Med Fac Associates, Dept Radiol, Div Nucl Med, Washington, DC USA
[4] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA USA
[5] Dana Farber Canc Inst, Dept Imaging, Boston, MA USA
[6] Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Radiol, 450 Brookline Ave, Boston, MA 02215 USA
关键词
POSITRON-EMISSION-TOMOGRAPHY; B-CELL LYMPHOMA; PROGRESSION-FREE SURVIVAL; ADVANCED HODGKIN LYMPHOMA; THERAPY F-18-FDG PET/CT; DETUDES DES LYMPHOMES; RISK-ADAPTED THERAPY; PROGNOSTIC VALUE; OPEN-LABEL; STAGE-III;
D O I
10.1053/j.semnuclmed.2022.10.004
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The clinical use and prognostic value of interim FDG-PET/CT (iPET/CT), which is performed after treatment initiation but prior to its completion, varies by lymphoma subtype. Evidence supporting the prognostic value of iPET/CT is more robust for classical Hodgkin lymphoma (cHL), and in this lymphoma subtype, response-adapted treatment approaches guided by iPET/CT are a widely used standard of care for first-line therapy. The data supporting use of iPET/CT among patients with non-Hodgkin lymphoma (NHL) is less well-established, but failure to achieve complete metabolic response on iPET/CT is generally considered a poor prognostic factor with likely consequences for progression free survival. This review will present the available evidence supporting use of iPET/CT in lymphoma patients, particularly as it relates to prognostication and the ability to inform response-adapted treatment strate-gies. The latter will be addressed through a discussion on the major iPET-response adapted clinical trials with mention of ongoing trials. Special attention will be given to cHL and a few subtypes of NHL, including diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), and peripheral T cell lymphoma (PTCL). Semin Nucl Med 53:371-388 (c) 2022 Elsevier Inc. All rights reserved.
引用
收藏
页码:371 / 388
页数:18
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