Mitochondrial-regulated Tregs: potential therapeutic targets for autoimmune diseases of the central nervous system

被引：3

作者：

Han, Aoya ^{[1
]}

Peng, Tingting ^{[1
]}

Xie, Yinyin ^{[1
]}

Zhang, Wanwan ^{[1
]}

Sun, Wenlin ^{[1
]}

Xie, Yi ^{[1
]}

Ma, Yunqing ^{[1
]}

Wang, Cui ^{[2
]}

Xie, Nanchang ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Neurol, Affiliated Hosp 1, Zhengzhou, Peoples R China

[2] Zhengzhou Univ, Dept Clin Lab, Affiliated Hosp 1, Zhengzhou, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

mitochondria; regulatory T cell; Foxp3; self-tolerance; central nervous system; autoimmune diseases; T-CELL DIFFERENTIATION; FOXP3; METABOLISM; HYPOXIA; DYSFUNCTION; HIF-1-ALPHA; ACTIVATION; INHIBITION; DEHYDROGENASE; INSTABILITY;

D O I：

10.3389/fimmu.2023.1301074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells (Tregs) can eliminate autoreactive lymphocytes, induce self-tolerance, and suppress the inflammatory response. Mitochondria, as the energy factories of cells, are essential for regulating the survival, differentiation, and function of Tregs. Studies have shown that patients with autoimmune diseases of the central nervous system, such as multiple sclerosis, neuromyelitis optica spectrum disorder, and autoimmune encephalitis, have aberrant Tregs and mitochondrial damage. However, the role of mitochondrial-regulated Tregs in autoimmune diseases of the central nervous system remains inconclusive. Therefore, this study reviews the mitochondrial regulation of Tregs in autoimmune diseases of the central nervous system and investigates the possible mitochondrial therapeutic targets.

引用

页数：9

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