Changes in heme oxygenase level during development affect the adult life of Drosophila melanogaster

被引：2

作者：

Bilska, Bernadetta ^{[1
]}

Damulewicz, Milena ^{[1
]}

Abaquita, Terence Al L. ^{[1
]}

Pyza, Elzbieta ^{[1
]}

机构：

[1] Jagiellonian Univ, Inst Zool & Biomed Res, Dept Cell Biol & Imaging, Krakow, Poland

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2023年 / 17卷

关键词：

neurons; glia; cap'n'collar; survival; behavior; sleep; aging; OXIDATIVE STRESS; GENE-EXPRESSION; ECDYSONE BIOSYNTHESIS; SIGNALING PATHWAY; ALZHEIMER-DISEASE; SEX-DIFFERENCES; P450; ENZYMES; NITRIC-OXIDE; IRON; MITOCHONDRIAL;

D O I：

10.3389/fncel.2023.1239101

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Heme oxygenase (HO) has been shown to control various cellular processes in both mammals and Drosophila melanogaster. Here, we investigated how changes in HO levels in neurons and glial cells during development affect adult flies, by using the TARGET Drosophila system to manipulate the expression of the ho gene. The obtained data showed differences in adult survival, maximum lifespan, climbing, locomotor activity, and sleep, which depended on the level of HO (after ho up-regulation or downregulation), the timing of expression (chronic or at specific developmental stages), cell types (neurons or glia), sex (males or females), and age of flies. In addition to ho, the effects of changing the mRNA level of the Drosophila CNC factor gene (NRF2 homolog in mammals and master regulator of HO), were also examined to compare with those observed after changing ho expression. We showed that HO levels in neurons and glia must be maintained at an appropriate physiological level during development to ensure the well-being of adults. We also found that the downregulation of ho in either neurons or glia in the brain is compensated by ho expressed in the retina.

引用

页数：19

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