MDMX in Cancer: A Partner of p53 and a p53-Independent Effector

被引：7

作者：

Lin, Wu ^{[1
]}

Yan, Yuxiang ^{[2
]}

Huang, Qingling ^{[1
]}

Zheng, Dali ^{[2
,3
]}

机构：

[1] Fujian Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Fuzhou, Peoples R China

[2] Fujian Med Univ, Sch & Hosp Stomatol, Fujian Key Lab Oral Dis, Fuzhou, Peoples R China

[3] Fujian Med Univ, Sch & Hosp Stomatol, Fujian Key Lab Oral Dis, 88 Jiao Tong Rd, Fuzhou 350004, Peoples R China

来源：

BIOLOGICS-TARGETS & THERAPY | 2024年 / 18卷

基金：

中国国家自然科学基金;

关键词：

MDMX; P53; cancer; inhibitors; SMALL-MOLECULE; MESSENGER-RNA; RING DOMAIN; THERAPEUTIC TARGET; GENE AMPLIFICATION; COLORECTAL-CANCER; STRUCTURAL BASIS; INHIBITOR MDM4; MUTANT P53; PROTEIN;

D O I：

10.2147/BTT.S436629

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The p53 tumor suppressor protein plays an important role in physiological and pathological processes. MDM2 and its homolog MDMX are the most important negative regulators of p53. Many studies have shown that MDMX promotes the growth of cancer cells by influencing the regulation of the downstream target gene of tumor suppressor p53. Studies have found that inhibiting the MDMX-p53 interaction can effectively restore the tumor suppressor activity of p53. MDMX has growth-promoting activities without p53 or in the presence of mutant p53. Therefore, it is extremely important to study the function of MDMX in tumorigenesis, progression and prognosis. This article mainly reviews the current research progress and mechanism on MDMX function, summarizes known MDMX inhibitors and provides new ideas for the development of more specific and effective MDMX inhibitors for cancer treatment.

引用

页码：61 / 78

页数：18

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