Fabrication, characterization and wound-healing properties of core-shell SF@chitosan/ZnO/Astragalus arbusculinus gum nanofibers

被引：6

作者：

Amiri, Zahra ^{[1
]}

Molavi, Amir Mahdi ^{[2
]}

Amani, Amir ^{[3
]}

Moqadam, Kurosh Hamzanlui ^{[4
]}

Vatanchian, Mehran ^{[5
]}

Hashemi, Seyyed Ahmad ^{[6
]}

Oroojalian, Fatemeh ^{[1
,3
]}

机构：

[1] North Khorasan Univ Med Sci, Sch Med, Dept Adv Technol, Bojnurd 7487794149, Iran

[2] Iranian Acad Ctr Educ Culture & Res ACECR, Dept Mat Res, Khorasan Razavi Branch, Mashhad 9177948974, Iran

[3] North Khorasan Univ Med Sci, Nat Prod & Med Plants Res Ctr, Bojnurd 7487794149, Iran

[4] North Khorasan Univ Med Sci, Bojnurd 7487794149, Iran

[5] North Khorasan Univ Med Sci, Dept Anat Sci Sch Med, Bojnurd 7487794149, Iran

[6] North Khorasan Univ Med Sci, Vector borne Dis Res Ctr, Bojnurd 7487794149, Iran

来源：

NANOMEDICINE | 2024年 / 19卷 / 06期

关键词：

adipose-derived stem cells; Astragalus arbusculinus; chitosan; electrospinning; silk fibroin; SCAFFOLD IMPLANTATION; STEM-CELLS; TISSUE; REPAIR; NANOTECHNOLOGY; ORGANS; DNA;

D O I：

10.2217/nnm-2023-0311

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Silk fibroin/chitosan/ZnO/Astragalus arbusculinus (Ast) gum fibrous scaffolds along with adipose-derived mesenchymal stem cells (ADSCs) were investigated for accelerating diabetic wound healing. Methods: Scaffolds with a core-shell structure and different compositions were synthesized using the electrospinning method. Biological in vitro investigations included antibacterial testing, cell viability analysis and cell attachment evaluation. In vivo experiments, including the chicken chorioallantoic membrane (CAM) test, were conducted to assess wound-healing efficacy and histopathological changes. Results: The incorporation of Ast to the silk fibroin@ chitosan/ZnO scaffold improved wound healing in diabetic mice. In addition, seeding of ADSCs on the scaffold accelerated wound healing. Conclusion: These findings suggest that the designed scaffold can be useful for skin regeneration applications.

引用

页码：499 / 518

页数：20

共 62 条

[1] Nanotechnology, and scaffold implantation for the effective repair of injured organs: An overview on hard tissue engineering [J].

Abdollahiyan, Parinaz ;

Oroojalian, Fatemeh ;

Hejazi, Maryam ;

de la Guardia, Miguel ;

Mokhtarzadeh, Ahad .

JOURNAL OF CONTROLLED RELEASE, 2021, 333 :391-417

[2] The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering [J].

Abdollahiyan, Parinaz ;

Oroojalian, Fatemeh ;

Mokhtarzadeh, Ahad .

JOURNAL OF CONTROLLED RELEASE, 2021, 332 :460-492

[3] Cutting-edge progress and challenges in stimuli responsive hydrogel microenvironment for success in tissue engineering today [J].

Abdollahiyan, Parinaz ;

Baradaran, Behzad ;

de la Guardia, Miguel ;

Oroojalian, Fatemeh ;

Mokhtarzadeh, Ahad .

JOURNAL OF CONTROLLED RELEASE, 2020, 328 :514-531

[4] Isolation, characterization, and antioxidant activity of neutral carbohydrates from Astragalus arbusculinus gum [J].

Ahmadi, Elham ;

Rezadoost, Hassan ;

Farimani, Mahdi Moridi .

SOUTH AFRICAN JOURNAL OF BOTANY, 2022, 146 :669-675

[5] Conductive and Semiconductive Nanocomposite-Based Hydrogels for Cardiac Tissue Engineering [J].

Alamdari, Sania Ghobadi ;

Alibakhshi, Abbas ;

de la Guardia, Miguel ;

Baradaran, Behzad ;

Mohammadzadeh, Reza ;

Amini, Mohammad ;

Kesharwani, Prashant ;

Mokhtarzadeh, Ahad ;

Oroojalian, Fatemeh ;

Sahebkar, Amirhossein .

ADVANCED HEALTHCARE MATERIALS, 2022, 11 (18)

[6] Antibacterial bi-layered polyvinyl alcohol (PVA)-chitosan blend nanofibrous mat loaded with Azadirachta indica (neem) extract [J].

Ali, Ayub ;

Shahid, Abdus ;

Hossain, Delwar ;

Islam, Nurul .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 138 :13-20

[7] IFATS Collection: Human Adipose-Derived Stem Cells Seeded on a Silk Fibroin-Chitosan Scaffold Enhance Wound Repair in a Murine Soft Tissue Injury Model [J].

Altman, Andrew M. ;

Yan, Yasheng ;

Matthias, Nadine ;

Bai, Xiaowen ;

Rios, Carmen ;

Mathur, Anshu B. ;

Song, Yao-Hua ;

Alt, Eckhard U. .

STEM CELLS, 2009, 27 (01) :250-258

[8] Investigation of angiogenesis and its mechanism using zinc oxide nanoparticle-loaded electrospun tissue engineering scaffolds [J].

Augustine, Robin ;

Dominic, Edwin Anto ;

Reju, Indu ;

Kaimal, Balarama ;

Kalarikkal, Nandakumar ;

Thomas, Sabu .

RSC ADVANCES, 2014, 4 (93) :51528-51536

[9]

Azari P., 2018, Journal of Public Health International, V1, P5, DOI DOI 10.14302/ISSN.2641-4538.JPHI-18-1975

[10] Electrospun protein nanofibers in healthcare: A review [J].

Babitha, S. ;

Rachita, Lakra ;

Karthikeyan, K. ;

Shoba, Ekambaram ;

Janani, Indrakumar ;

Poornima, Balan ;

Sai, K. Purna .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 523 (01) :52-90

← 1 2 3 4 5 6 7 →