HIV-Host Cell Interactions

被引：22

作者：

Masenga, Sepiso K. ^{[1
,2
]}

Mweene, Bislom C. ^{[1
]}

Luwaya, Emmanuel ^{[1
]}

Muchaili, Lweendo ^{[1
]}

Chona, Makondo ^{[1
]}

Kirabo, Annet ^{[2
]}

机构：

[1] Mulungushi Univ, Sch Med & Hlth Sci, HAND Res Grp, Livingstone Campus, Livingstone 10101, Zambia

[2] Vanderbilt Univ, Med Ctr, Dept Med, Div Clin Pharmacol, Room 536 Robinson Res Bldg, Nashville, TN 37232 USA

来源：

CELLS | 2023年 / 12卷 / 10期

基金：

美国国家卫生研究院;

关键词：

HIV; AIDS; immunity; cells; T- cell exhaustion; CCR5; CXCR4; sex; dendritic cells; CD4(+) T cells; T lymphocytes; IMMUNODEFICIENCY-VIRUS TYPE-1; INTERFERON REGULATORY FACTOR; TOLL-LIKE RECEPTORS; COMPLEX CLASS-I; INNATE IMMUNITY; SEX-DIFFERENCES; GENE-EXPRESSION; T-CELLS; ENVELOPE GLYCOPROTEIN; ANTIGEN PRESENTATION;

D O I：

10.3390/cells12101351

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The development of antiretroviral drugs (ARVs) was a great milestone in the management of HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells and prolonging life. However, an effective treatment has remained elusive for four decades due to the successful immune evasion mechanisms of the virus. A thorough understanding of the molecular interaction of HIV with the host cell is essential in the development of both preventive and curative therapies for HIV infection. This review highlights several inherent mechanisms of HIV that promote its survival and propagation, such as the targeting of CD4(+) lymphocytes, the downregulation of MHC class I and II, antigenic variation and an envelope complex that minimizes antibody access, and how they collaboratively render the immune system unable to mount an effective response.

引用

页数：25

共 50 条

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PUDNEY, J
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TISSUE & CELL, 1994, 26 (04): : 539 - 550
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HAASE, AT
EMBRETSON, JE
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BENEKE, J
WOLINSKY, S
TILL, M
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Young, John A. T.
FASEB JOURNAL, 2013, 27
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Pinney, John W.
Dickerson, Jonathan E.
Fu, William
Sanders-Beer, Brigitte E.
Ptak, Roger G.
Robertson, David L.
AIDS, 2009, 23 (05) : 549 - 554
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Haynes, Barton F.
Shaw, George M.
Korber, Bette
Kelsoe, Garnett
Sodroski, Joseph
Hahn, Beatrice H.
Borrow, Persephone
McMichael, Andrew J.
CELL HOST & MICROBE, 2016, 19 (03) : 292 - 303
[6] Visualizing and quantifying HIV-host interactions with fluorescence microscopy
Hendrix, Jelle
Debyser, Zeger
Hofkens, Johan
Engelborghs, Yves
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2011, 40 : 48 - 48
[7] HIV-host interactions: research challenges and future directions
Alcami, J.
FEBS JOURNAL, 2012, 279 : 42 - 42
[8] HIV-host interactions: vital to the virus and key to its inhibition
Trkola, A
CURRENT OPINION IN MICROBIOLOGY, 2004, 7 (04) : 407 - 411
[9] A small leak will sink a great ship: HIV-host interactions
Herold, Nikolas
Kraeusslich, Hans-Georg
Mueller, Barbara
FROM MOLECULES TO LIVING ORGANISMS: AN INTERPLAY BETWEEN BIOLOGY AND PHYSICS, 2016, : 25 - 42
[10] The Role of Tumor Suppressor p53 Protein in HIV-Host Cell Interactions
Bakhanashvili, Mary
CELLS, 2024, 13 (18)

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