COVID-19 Biomarkers Comparison: Children, Adults and Elders

被引:8
作者
Capraru, Ionut Dragos [1 ]
Vulcanescu, Dan Dumitru [2 ,3 ]
Bagiu, Iulia Cristina [2 ,3 ]
Horhat, Florin George [2 ,3 ]
Popescu, Irina Maria [1 ]
Baditoiu, Luminita Mirela [1 ]
Muntean, Delia [2 ,4 ]
Licker, Monica [2 ,4 ]
Radulescu, Matilda [2 ]
Mot, Ion Cristian [5 ]
Diaconu, Mircea Mihai [6 ]
Marian, Catalin [7 ]
机构
[1] Victor Babes Univ Med & Pharm, Dept Epidemiol, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[2] Victor Babes Univ Med & Pharm, Multidisciplinary Res Ctr Antimicrobial Resistance, Dept Microbiol, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[3] Emergency Hosp Children Louis Turcanu, Clin Lab, Timisoara 300011, Romania
[4] Pius Brinzeu Cty Clin Emergency Hosp, Microbiol Lab, 156 L Rebreanu, Timisoara 300723, Romania
[5] Victor Babes Univ Med & Pharm, ENT Dept, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[6] Victor Babes Univ Med & Pharm, Dept Obstet & Gynecol, Timisoara 300041, Romania
[7] Victor Babes Univ Med & Pharm, Dept Biochem, Eftimie Murgu Sq 2, Timisoara 300041, Romania
来源
MEDICINA-LITHUANIA | 2023年 / 59卷 / 05期
关键词
COVID-19; SARS-CoV-2; biomarkers; children; adults; elders; HOSPITALIZED-PATIENTS; MORTALITY; SARS-COV-2; PNEUMONIA; SEVERITY;
D O I
10.3390/medicina59050877
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of Romania, and compare their potential use as biomarkers for intensive care units (ICU) admission and death in children, adults and elders. Materials and Methods: this study is a retrospective cohort study, performed on patients positively diagnosed with COVID-19. Available CRP, LDH, CK 25-OH vitamin D, ferritin, HDL cholesterol and clinical severity were recorded. The following were assessed: median group differences, association, correlation and receiver operating characteristic. Results: 381 children, 614 adults and 381 elders were studied between 1 March 2021 and 1 March 2022. Most children and adults presented mild symptomatology (53.28%, 35.02%, respectively), while most elders presented severe symptomatology (30.04%). ICU admission was 3.67% for children, 13.19% for adults and 46.09% for elders, while mortality was 0.79% for children, 8.63% for adults and 25.1% for elders. With the exception of CK, all other biomarkers showed some significant associations with clinical severity, ICU admission and death. Conclusions: CRP, LDH, 25-OH vitamin D, ferritin and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges.
引用
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页数:18
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