Non-invasive estimation of hemoglobin, bilirubin and oxygen saturation of neonates simultaneously using whole optical spectrum analysis at point of care

被引：10

作者：

Banerjee, Amrita ^{[1
,2
,3
]}

Bhattacharyya, Neha ^{[4
,5
]}

Ghosh, Ria ^{[5
]}

Singh, Soumendra ^{[5
,6
,7
]}

Adhikari, Aniruddha ^{[5
,8
]}

Mondal, Susmita ^{[5
]}

Roy, Lopamudra ^{[2
,9
]}

Bajaj, Annie ^{[3
]}

Ghosh, Nilanjana ^{[3
]}

Bhushan, Aman ^{[10
]}

Goswami, Mahasweta ^{[2
]}

Ahmed, Ahmed S. A. ^{[11
]}

Moussa, Ziad ^{[12
]}

Mondal, Pulak ^{[4
]}

Mukhopadhyay, Subhadipta ^{[1
]}

Bhattacharyya, Debasis ^{[13
]}

Chattopadhyay, Arpita ^{[14
,15
]}

Ahmed, Saleh A. ^{[16
]}

Mallick, Asim Kumar ^{[3
]}

Pal, Samir Kumar ^{[5
]}

机构：

[1] Jadavpur Univ, Dept Phys, 188, Raja SC Mallick Rd, Kolkata 700032, India

[2] S N Bose Natl Ctr Basic Sci, Tech Res Ctr, Block JD,Sect 3, Kolkata 700106, W Bengal, India

[3] Nil RatanSircar Med Coll & Hosp, Dept Paediat Med, 138, AJC Bose Rd, Kolkata 700014, India

[4] Univ Calcutta, Dept Radio Phys & Elect, 92, Acharya Prafulla Chandra Rd, Kolkata 700009, India

[5] S N Bose Natl Ctr Basic Sci, Dept Chem & Biol Sci, Block JD,Sect 3, Kolkata 700106, India

[6] Neo Care Inc, 27, Parker St, Dartmouth, NS B2Y 2W1, Canada

[7] Dalhousie Univ, Elect & Comp Engn Dept, 6299 South St, Halifax, NS B3H 4R2, Canada

[8] Univ Calif Los Angeles, Chem & Biomol Engn, Los Angeles, CA 90095 USA

[9] Dept Appl Opt & Photon, JD-2, Sect III, Kolkata 700106, W Bengal, India

[10] Thapar Inst Engn & Technol, Dept Biotechnol, Bhadson Rd, Patiala 147004, Punjab, India

[11] Assiut Univ, Fac Med, Assiut 71516, Egypt

[12] United Arab Emirates Univ, Coll Sci, Dept Chem, PO Box 15551, Abu Dhabi, U Arab Emirates

[13] Nil Ratan Sircar Med Coll & Hosp, Dept Gynecol & Obstet, 138, AJC Bose Rd, Kolkata 700014, India

[14] Techno Int, Dept Basic Sci & Humanities, Kolkata 700156, India

[15] Sister Nivedita Univ, Dept Phys, Kolkata, India

[16] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, Mecca 21955, Saudi Arabia

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

PULSE COOXIMETER; BLOOD; ACCURACY; OXIMETRY; HYPERBILIRUBINEMIA; SERUM;

D O I：

10.1038/s41598-023-29041-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The study was aimed to evaluate the performance of a newly developed spectroscopy-based non-invasive and noncontact device (SAMIRA) for the simultaneous measurement of hemoglobin, bilirubin and oxygen saturation as an alternative to the invasive biochemical method of blood sampling. The accuracy of the device was assessed in 4318 neonates having incidences of either anemia, jaundice, or hypoxia. Transcutaneous bilirubin, hemoglobin and blood saturation values were obtained by the newly developed instrument which was corroborated with the biochemical blood tests by expert clinicians. The instrument is trained using Artificial Neural Network Analysis to increase the acceptability of the data. The artificial intelligence incorporated within the instrument determines the disease condition of the neonate. The Pearson's correlation coefficient, r was found to be 0.987 for hemoglobin estimation and 0.988 for bilirubin and blood gas saturation respectively. The bias and the limits of agreement for the measurement of all the three parameters were within the clinically acceptance limit.

引用

页数：17

共 66 条

[1]

Alkhotani A., 2014, SCI REP-UK, V4, P1

[2] Evaluation of the blood gas analyzer GEM® PREMIER 3000 [J].

Bénéteau-Burnat, B ;

Bocque, MC ;

Lorin, A ;

Martin, C ;

Vaubourdolle, M .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2004, 42 (01) :96-101

[3] Noninvasive measurement of total serum bilirubin in a multiracial predischarge newborn population to assess the risk of severe hyperbilirubinemia [J].

Bhutani, VK ;

Gourley, GR ;

Adler, S ;

Kreamer, B ;

Dalin, C ;

Johnson, LH .

PEDIATRICS, 2000, 106 (02) :E17

[4]

Bizuneh AD., 2020, BMJ PAEDIATR OPEN, V4, pe000380

[5] STATISTICS NOTES .1. CORRELATION, REGRESSION, AND REPEATED DATA [J].

BLAND, JM ;

ALTMAN, DG .

BRITISH MEDICAL JOURNAL, 1994, 308 (6933) :896-896

[6] STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [J].

BLAND, JM ;

ALTMAN, DG .

LANCET, 1986, 1 (8476) :307-310

[7] Limitations and Opportunities of Transcutaneous Bilirubin Measurements [J].

Bosschaart, Nienke ;

Kok, Joke H. ;

Newsum, Astrid M. ;

Ouweneel, Dagmar M. ;

Mentink, Rosaline ;

van Leeuwen, Ton G. ;

Aalders, Maurice C. G. .

PEDIATRICS, 2012, 129 (04) :689-694

[8]

Brits H, 2018, AFR J PRIM HEALTH CA, V10

[9] Comparison of heart rate and oxygen saturation measurements from Masimo and Nellcor pulse oximeters in newly born term infants [J].

Dawson, J. A. ;

Saraswat, A. ;

Simionato, L. ;

Thio, M. ;

Kamlin, C. O. F. ;

Owen, L. S. ;

Schmoelzer, G. M. ;

Davis, P. G. .

ACTA PAEDIATRICA, 2013, 102 (10) :955-960

[10] Drug therapy: Neonatal hyperbilirubinemia. [J].

Dennery, PA ;

Seidman, DS ;

Stevenson, DK .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (08) :581-590

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