Down syndrome and leukemia: from basic mechanisms to clinical advances

被引：17

作者：

Baruchel, Andre ^{[1
,2
]}

Bourquin, Jean-Pierre ^{[3
]}

Crispino, John ^{[4
]}

Cuartero, Sergi ^{[5
]}

Hasle, Henrik ^{[6
]}

Hitzler, Johann ^{[7
]}

Klusmann, Jan -Henning ^{[8
]}

Izraeli, Shai ^{[9
,10
]}

Lane, Andrew A. ^{[11
]}

Malinge, Sebastienn ^{[12
]}

Rabin, Karen R. ^{[13
]}

Roberts, Irene ^{[14
]}

Ryeom, Sandra ^{[15
]}

Tasian, Sarah K. ^{[16
,17
]}

Wagenblast, Elvin ^{[18
]}

机构：

[1] Hop Univ Robert Debre, APHP, Paris, France

[2] Univ Paris Cite, Paris, France

[3] Univ Childrens Hosp, Zurich, Switzerland

[4] St Jude Childrens Res Hosp, Memphis, TN USA

[5] Josep Carreras Leukemia Res Inst, Barcelona, Spain

[6] Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Aarhus, Denmark

[7] Hosp Sick Children, Toronto, ON, Canada

[8] Goethe Univ Frankfurt, Dept Pediat, Frankfurt, Germany

[9] Schneider Childrens Med Ctr Israel, Petah Tiqwa, Israel

[10] Tel Aviv Univ, Sackler Sch Med, Dept Human Mol Genet & Biochem, Tel Aviv, Israel

[11] Dana Farber Canc Inst, Boston, MA USA

[12] Telethon Kids Inst, Canc Ctr, Perth, WA, Australia

[13] Baylor Coll Med, Texas Childrens Canc Ctr, Houston, TX USA

[14] Univ Oxford, Oxford, England

[15] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Dept Surg, Irving Med Ctr, New York, NY 10032 USA

[16] Childrens Hosp Philadelphia, Philadelphia, PA USA

[17] Univ Penn, Perelman Sch Med, Philadelphia, PA USA

[18] Icahn Sch Med Mt Sinai, New York, NY USA

来源：

HAEMATOLOGICA | 2023年 / 108卷 / 10期

基金：

欧洲研究理事会;

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; MYELOID-LEUKEMIA; SOLID TUMORS; MEGAKARYOBLASTIC LEUKEMIA; CHILDREN; RISK; POPULATION; PREVENTION; TRISOMY-21; MUTATIONS;

D O I：

10.3324/haematol.2023.283225

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades. Despite improved treatment regimens and significant progress in iden - tifying genes on chromosome 21 and the mechanisms by which they drive leukemogenesis, there is still much that is un-known. A focused group of scientists and clinicians with expertise in leukemia and DS met in October 2022 at the Jerome Lejeune Foundation in Paris, France for the 1st International Symposium on Down Syndrome and Leukemia. This meeting was held to discuss the most recent advances in treatment regimens and the biology underlying the initiation, progression, and relapse of acute lymphoblastic leukemia and acute myeloid leukemia in children with DS. This review provides a sum-mary of what is known in the field, challenges in the management of DS patients with leukemia, and key questions in the field.

引用

页码：2570 / 2581

页数：12

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