Research Progress in Calcitonin Gene-Related Peptide and Bone Repair

被引：26

作者：

Wang, Qichang ^{[1
,2
,3
,4
]}

Qin, Haotian ^{[1
,2
]}

Deng, Jiapeng ^{[1
,2
]}

Xu, Huihui ^{[1
,2
]}

Liu, Su ^{[1
,2
]}

Weng, Jian ^{[1
,2
]}

Zeng, Hui ^{[1
,2
,4
]}

机构：

[1] Peking Univ, Shenzhen Hosp, Natl & Local Joint Engn Res Ctr Orthopaed Biomat, Shenzhen 518036, Peoples R China

[2] Peking Univ, Shenzhen Hosp, Dept Bone & Joint Surg, Shenzhen 518036, Peoples R China

[3] Shenzhen Univ, Sch Clin Med, Dept Med, Shenzhen 518061, Peoples R China

[4] Shenzhen Key Lab Orthopaed Dis & Biomat Res, Shenzhen 518036, Peoples R China

来源：

BIOMOLECULES | 2023年 / 13卷 / 05期

基金：

中国国家自然科学基金;

关键词：

calcitonin gene-related peptide; osteogenic effect; immunomodulation; bone repair; MESENCHYMAL STEM-CELLS; COMPONENT PROTEIN RCP; CGRP-RECEPTOR; SUBSTANCE-P; OSTEOGENIC DIFFERENTIATION; STIMULATES PROLIFERATION; SIGNAL-TRANSDUCTION; NERVE-FIBERS; ALPHA-CGRP; RAT;

D O I：

10.3390/biom13050838

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcitonin gene-related peptide (CGRP) has 37 amino acids. Initially, CGRP had vasodilatory and nociceptive effects. As research progressed, evidence revealed that the peripheral nervous system is closely associated with bone metabolism, osteogenesis, and bone remodeling. Thus, CGRP is the bridge between the nervous system and the skeletal muscle system. CGRP can promote osteogenesis, inhibit bone resorption, promote vascular growth, and regulate the immune microenvironment. The G protein-coupled pathway is vital for its effects, while MAPK, Hippo, NF-?B, and other pathways have signal crosstalk, affecting cell proliferation and differentiation. The current review provides a detailed description of the bone repair effects of CGRP, subjected to several therapeutic studies, such as drug injection, gene editing, and novel bone repair materials.

引用

页数：18

共 135 条

[1] A cDNA encoding the calcitonin gene-related peptide type 1 receptor [J].