Advanced delivery systems for peptide antibiotics

被引：35

作者：

Cesaro, Angela ^{[1
,2
,3
,4
,5
]}

Lin, Shuangzhe ^{[1
,2
,3
,4
,5
]}

Pardi, Norbert ^{[6
]}

de la Fuente-Nunez, Cesar ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Penn, Machine Biol Grp, Dept Psychiat, Philadelphia, PA 19104 USA

[2] Univ Penn, Inst Biomed Informat, Inst Translat Med & Therapeut, Perelman Sch Med,Dept Microbiol, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Engn & Appl Sci, Dept Chem & Biomol Engn, Philadelphia, PA 19104 USA

[5] Univ Penn, Penn Inst Computat Sci, Philadelphia, PA 19104 USA

[6] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2023年 / 196卷

基金：

美国国家卫生研究院;

关键词：

Infectious diseases; Antimicrobial peptides; Antibiotic resistance; Drug-delivery; Cell-based delivery systems; mRNA-lipid nanoparticle-based therapy; MESSENGER-RNA VACCINES; NANOSTRUCTURED LIPID CARRIERS; SEC-DEPENDENT BACTERIOCIN; ANTIMICROBIAL PEPTIDES; GENETIC-CHARACTERIZATION; ENTEROCOCCUS-FAECIUM; DRUG-DELIVERY; AMINO-ACID; EXPRESSION; NANOPARTICLES;

D O I：

10.1016/j.addr.2023.114733

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antimicrobial peptides (AMPs) hold promise as alternatives to traditional antibiotics for preventing and treating multidrug-resistant infections. Although they have potent antimicrobial efficacy, AMPs are mainly limited by their susceptibility to proteases and potential off-site cytotoxicity. Designing the right delivery system for peptides can help to overcome such limitations, thus improving the pharmacokinetic and pharmacodynamic profiles of these drugs. The versatility of peptides and their genetically encodable structure make them suitable for both conventional and nucleoside-based formulations. In this review, we describe the main drug delivery procedures developed so far for peptide antibiotics: lipid nanoparti-cles, polymeric nanoparticles, hydrogels, functionalized surfaces, and DNA-and RNA-based delivery systems. (c) 2023 Elsevier B.V. All rights reserved.

引用

页数：20

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