Amino acid metabolism, redox balance and epigenetic regulation in cancer

被引：21
|
作者：
Li, Xiang [1 ]
Zhang, Hong-Sheng [1 ,2 ]
机构：
[1] Beijing Univ Technol, Fac Environm & Life, Beijing, Peoples R China
[2] Beijing Univ Technol, Fac Environm & Life, Pingleyuan 100, Beijing 100124, Peoples R China
来源：
FEBS JOURNAL | 2024年 / 291卷 / 03期
基金：
北京市自然科学基金;
关键词：
amino acids; cancer; epigenetic regulation; metabolism; redox balance; GLUTAMINE-METABOLISM; PANCREATIC-CANCER; CELLS; METHYLATION; TRYPTOPHAN; RESISTANCE; SERINE; GROWTH; DEHYDROGENASE; PROGRESSION;
D O I：
10.1111/febs.16803
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amino acids act as versatile nutrients driving cell growth and survival, especially in cancer cells. Amino acid metabolism comprises numerous metabolic networks and is closely linked with intracellular redox balance and epigenetic regulation. Reprogrammed amino acid metabolism has been recognized as a ubiquitous feature in tumour cells. This review outlines the metabolism of several primary amino acids in cancer cells and highlights the pivotal role of amino acid metabolism in sustaining redox homeostasis and regulating epigenetic modification in response to oxidative and genetic stress in cancer cells.
引用
收藏
页码：412 / 429
页数：18
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