Effect of amphiphilic phosphorous dendrons on the conformation, secondary structure, and zeta potential of albumin and thrombin

被引：1

作者：

Terehova, Maria ^{[1
]}

Magiera, Jakub ^{[2
]}

Qiu, Jieru ^{[3
,4
]}

Majoral, Jean-Pierre ^{[3
,4
]}

Shi, Xiangyang ^{[5
,6
]}

Mignani, Serge ^{[6
,7
]}

Ionov, Maksim ^{[2
]}

Waczulikova, Iveta ^{[8
]}

Bryszewska, Maria ^{[2
]}

Shcharbin, Dzmitry ^{[1
]}

机构：

[1] Natl Acad Sci Belarus, Inst Biophys & Cell Engn, Akad 27, Minsk 220072, BELARUS

[2] Univ Lodz, Fac Biol & Environm Protect, Dept Gen Biophys, 141-143 Pomorska St, PL-90236 Lodz, Poland

[3] CNRS, Lab Chim Coordinat, 205 Route Narbonne, F-31077 Toulouse 4, France

[4] Univ Toulouse, 118 Route Narbonne, F-31077 Toulouse 4, France

[5] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

[6] Univ Madeira, CQM Ctr Quim Madeira, MMRG, Campus Penteada, P-9020105 Funchal, Portugal

[7] Univ Paris 05, Lab Chim & Biochim Pharmacol & Toxicol, PRES Sorbonne Paris Cite, CNRS UMR 860, 45 Rue St Peres, F-75006 Paris, France

[8] Comenius Univ, Fac Math Phys & Informat, Dept Nucl Phys & Biophys, Mlynska Dolina F1, Bratislava 84248, Slovakia

来源：

POLYMER BULLETIN | 2023年 / 80卷 / 08期

关键词：

Amphiphilic dendrons; Dendritic nanoparticles; Drug-delivery systems; Biocompatibility; DENDRIMERS;

D O I：

10.1007/s00289-022-04512-8

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Amphiphilic dendrons are highly branched synthetic polymeric soft nanoparticles that possess properties of both dendrimers and micelles. Such properties allow dendrons to become promising delivery systems for targeted delivery. While much attention is focused on the design and biological effect of a drug-delivery system, the nature of its interaction with surrounding tissues-their biocompatibility-is crucial for further optimization. The biocompatibility and biological effects of some amphiphilic phosphorus dendrons on human serum albumin and thrombin are investigated in this report. The results from protein fluorescence, circular dichroism, and zeta potential experiments showed that the dendrons of the first generation have a lesser impact on protein molecules than the dendrons of the second generation and therefore tend to be more biocompatible.

引用

页码：9181 / 9193

页数：13

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