The ins-and-outs of exosome biogenesis, secretion, and internalization

被引：166

作者：

Arya, Subhash B.

Collie, Samuel P. ^{[1
,2
]}

Parent, Carole A. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Cellular & Mol Biol Grad Program, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

来源：

TRENDS IN CELL BIOLOGY | 2024年 / 34卷 / 02期

关键词：

MEMBRANE CONTACT SITES; MULTIVESICULAR BODIES; SURFACE-PROTEINS; PRION PROTEIN; ESCRT-III; VESICLES; RELEASE; ER; ENDOCYTOSIS; TRANSPORT;

D O I：

10.1016/j.tcb.2023.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exosomes are specialized cargo delivery vesicles secreted from cells by fusion of multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of exosomes during physiological and pathological events has been extensively reported, there remains a lack of understanding of the mechanisms that regulate exosome biogenesis, secretion, and internalization. Recent technological and methodological advances now provide details about MVB/exosome structure as well as the pathways of exosome biogenesis, secretion, and uptake. In this review, we outline our current understanding of these processes and highlight outstanding questions following on recent discoveries in the field.

引用

收藏

页码：90 / 108

页数：19

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