Porcine Placenta Peptide Inhibits UVB-Induced Skin Wrinkle Formation and Dehydration: Insights into MAPK Signaling Pathways from In Vitro and In Vivo Studies

被引:5
作者
Sim, Woo-Jin [1 ]
Kim, Jinhak [2 ]
Baek, Kwang-Soo [2 ]
Lim, Wonchul [1 ,3 ]
Lim, Tae-Gyu [1 ,3 ]
机构
[1] Sejong Univ, Dept Food Sci & Biotechnol, Seoul 05006, South Korea
[2] Daehan Chemtech Co Ltd, R&D Div, Gwacheon Si 13840, South Korea
[3] Sejong Univ, Carbohydrate Bioprod Res Ctr, Seoul 05006, South Korea
关键词
porcine placenta; ultraviolet; wrinkle; dehydration; SKH-1; MAPK; EXPRESSION; EXTRACT; P38; COLLAGEN; STRESS; DAMAGE; JNK;
D O I
10.3390/ijms25010083
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Excessive exposure to ultraviolet (UV) radiation from sunlight accelerates skin aging, leading to various clinical manifestations such as wrinkles, dryness, and loss of elasticity. This study investigated the protective effects of porcine placenta peptide (PPP) against UVB-induced skin photoaging. Female hairless SKH-1 mice were orally administered PPP for 12 weeks, followed by UVB irradiation. PPP significantly reduced wrinkle formation, improved skin moisture levels, and prevented collagen degradation. Mechanistically, PPP inhibited the expression of matrix metalloproteinases (MMPs) and upregulated collagen production. Moreover, PPP elevated hyaluronic acid levels, contributing to enhanced skin hydration. Additionally, PPP demonstrated antioxidant properties by increasing the expression of the antioxidant enzyme GPx-1, thereby reducing UVB-induced inflammation. Further molecular analysis revealed that PPP suppressed the activation of p38 MAP kinase and JNK signaling pathways, crucial mediators of UV-induced skin damage. These findings highlight the potential of porcine placental peptides as a natural and effective intervention against UVB-induced skin photoaging. The study provides valuable insights into the mechanisms underlying the protective effects of PPP, emphasizing its potential applications in skincare and anti-aging formulations.
引用
收藏
页数:16
相关论文
共 42 条
[1]   Photochemoprevention of ultraviolet B signaling and photocarcinogenesis [J].
Afaq, F ;
Adhami, VM ;
Mukhtar, H .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 571 (1-2) :153-173
[2]   NF-κB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox [J].
Anrather, J ;
Racchumi, G ;
Iadecola, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (09) :5657-5667
[3]   Free radicals in biology and medicine: From inflammation to biotechnology [J].
Aruoma, Okezie I. ;
Grootveld, Martin ;
Bahorun, Theeshan .
BIOFACTORS, 2006, 27 (1-4) :1-3
[4]   Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin [J].
Aziz, Jazli ;
Shezali, Hafiz ;
Radzi, Zamri ;
Yahya, Noor Azlin ;
Abu Kassim, Noor Hayaty ;
Czernuszka, Jan ;
Rahman, Mohammad Tariqur .
SKIN PHARMACOLOGY AND PHYSIOLOGY, 2016, 29 (04) :190-203
[5]   Molecular hydrogen protects against oxidative stress-induced RAW 264.7 macrophage cells through the activation of Nrf2 and inhibition of MAPK signaling pathway [J].
Begum, Rahima ;
Kim, Cheol-Su ;
Fadriquela, Ailyn ;
Bajgai, Johny ;
Jing, Xingyu ;
Kim, Dong-Heui ;
Kim, Soo-Ki ;
Lee, Kyu-Jae .
MOLECULAR & CELLULAR TOXICOLOGY, 2020, 16 (02) :103-118
[6]  
Bukhari SNA, 2018, INT J BIOL MACROMOL, V120, P1682, DOI [10.1016/j.fibiomac.2018.09.188, 10.1016/j.ijbiomac.2018.09.188]
[7]   Plant extracts and natural compounds used against UVB-induced photoaging [J].
Cavinato, Maria ;
Waltenberger, Birgit ;
Baraldo, Giorgia ;
Grade, Carla V. C. ;
Stuppner, Hermann ;
Jansen-Durr, Pidder .
BIOGERONTOLOGY, 2017, 18 (04) :499-516
[8]   Effect of collagen degradation on the mechanical behavior and wrinkling of skin [J].
Chavoshnejad, Poorya ;
Foroughi, Ali H. ;
Dhandapani, Niranjana ;
German, Guy K. ;
Razavi, Mir Jalil .
PHYSICAL REVIEW E, 2021, 104 (03)
[9]   Alpha-Fetoprotein, Identified as a Novel Marker for the Antioxidant Effect of Placental Extract, Exhibits Synergistic Antioxidant Activity in the Presence of Estradiol [J].
Choi, Hye Yeon ;
Kim, Seung Woo ;
Kim, BongWoo ;
Lee, Hae Na ;
Kim, Su-Jeong ;
Song, Minjung ;
Kim, Sol ;
Kim, Jungho ;
Kim, Young Bong ;
Kim, Jin-Hoi ;
Cho, Ssang-Goo .
PLOS ONE, 2014, 9 (06)
[10]   Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets [J].
Choi, Ki-Seok ;
Kundu, Joydeb Kumar ;
Chun, Kyung-Soo ;
Na, Hye-Kyung ;
Surh, Young-Joon .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2014, 559 :38-45