Delivery of a sebum modulator by an engineered skin microbe in mice

被引：8

作者：

Knodlseder, Nastassia ^{[1
]}

Fabrega, Maria-Jose ^{[1
]}

Santos-Moreno, Javier ^{[1
]}

Manils, Joan ^{[2
,3
]}

Toloza, Lorena ^{[1
]}

Marin Vilar, Maria ^{[1
,14
]}

Fernandez, Cristina ^{[1
]}

Broadbent, Katrina ^{[4
]}

Maruotti, Julien ^{[5
]}

Lemenager, Helene ^{[5
]}

Carolis, Carlo ^{[4
]}

Zouboulis, Christos C. ^{[6
,7
,8
,9
]}

Soler, Concepcio ^{[2
,10
]}

Lood, Rolf ^{[11
]}

Bruggemann, Holger ^{[12
]}

Guell, Marc ^{[1
,13
]}

机构：

[1] Univ Pompeu Fabra, Dept Med & Life Sci, Barcelona, Spain

[2] Inst Invest Biomed Bellvitge, Oncobell Program, Immun Inflammat & Canc Grp, Barcelona, Spain

[3] Univ Barcelona, Sch Med, Dept Pathol & Expt Therapy, Immunol Unit,Serra Hunter Programme, Barcelona 08007, Spain

[4] Ctr Genom Regulat, Prot Technol Facil, Barcelona, Spain

[5] Phenocell SAS, Grasse, France

[6] Hsch klin Dermatol Venerol & Allergol, Dessau Rosslau, Germany

[7] Stadt Klinikum Dessau, Dessau Rosslau, Germany

[8] Med Hsch Brandenburg Theodor Fontane, Dessau Rosslau, Germany

[9] Fak Gesundheitswissensch Brandenburg, Dessau Rosslau, Germany

[10] Univ Barcelona, Sch Med, Dept Pathol & Expt Therapy, Immunol Unit, Barcelona, Spain

[11] Lund Univ, Dept Clin Sci, Div Infect Med, Lund, Sweden

[12] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[13] ICREA Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain

[14] Vall Hebron Inst Oncol, Barcelona, Spain

来源：

NATURE BIOTECHNOLOGY | 2024年 / 42卷 / 11期

基金：

欧盟地平线“2020”;

关键词：

GELATINASE-ASSOCIATED LIPOCALIN; PROPIONIBACTERIUM-ACNES; ISOTRETINOIN; BACTERIA; TRANSFORMATION; SYSTEM;

D O I：

10.1038/s41587-023-02072-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production. An engineered skin microbe produces a therapeutic molecule that reduces sebum in mice.

引用

页码：1661 / 1666

页数：13

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