Hippocampal volume mediates the relationship of parental rejection in childhood with social cognition in healthy adults

被引:0
作者
Kawamoto, Marino [1 ,2 ]
Takagishi, Haruto [2 ]
Ishihara, Toru [3 ]
Takagi, Shunsuke [1 ]
Kanai, Ryota [4 ]
Sugihara, Genichi [1 ]
Takahashi, Hidehiko [1 ,2 ,5 ]
Matsuda, Tetsuya [2 ]
机构
[1] Tokyo Med & Dent Univ, Grad Sch, Dept Psychiat & Behav Sci, Tokyo, Japan
[2] Tamagawa Univ, Brain Sci Inst, Tokyo, Japan
[3] Kobe Univ, Grad Sch Human Dev & Environm, Kobe, Japan
[4] Araya Inc, Tokyo, Japan
[5] Tokyo Med & Dent Univ, Ctr Brain Integrat Res, Tokyo, Japan
基金
日本科学技术振兴机构;
关键词
DIFFERENTIAL NEURAL RESPONSE; SEXUAL-ABUSE; AMYGDALA VOLUME; BRAIN; MALTREATMENT; STRESS; DISORDER; PREDICTS; FEAR; METAANALYSIS;
D O I
10.1038/s41598-023-46512-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Childhood abuse reduces hippocampal and amygdala volumes and impairs social cognition, including the ability to recognize facial expressions. However, these associations have been studied primarily in individuals with a history of severe abuse and psychiatric symptoms; researchers have not determined whether these associations can also be observed in healthy adults. In the present study, we analyzed data from 400 healthy adults (208 men and 192 women) at Tamagawa University. Parental rejection reflecting childhood abuse was assessed using the short form of Egna Minnen Betraffande Uppfostran, while social cognition was assessed using the "Fake Smile Detection Task." Hippocampal and amygdala volumes were extracted from T1-weighted magnetic resonance imaging data using FreeSurfer. We found that greater parental rejection resulted in smaller hippocampal and amygdala volumes and poorer performance in the Fake Smile Detection Task. Structural equation modeling analysis supported the model that hippocampal volume mediates maternal rejection effect on performance on the Fake Smile Detection Task, with involvement of the amygdala. These findings are in line with the structural and functional connectivity found between the hippocampus and amygdala and their joint involvement in social cognition. Therefore, parental rejection may affect hippocampal and amygdala volumes and social cognitive function even in symptom-free adults.
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页数:12
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