The infusion of Baccharis spicata (Lam.) Baill (Asteraceae) has antiviral activity against hepatitis B virus without cytotoxic effects against several cell lines

被引：0

作者：

Ortega, Joseph T. ^{[1
]}

Agudelo, Ignacio ^{[2
,3
]}

Ricco, Rafael Alejandro ^{[2
,3
]}

Cavallaro, Lucia Vicenta ^{[1
]}

Campos, Rodolfo ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Virol, Buenos Aires, Argentina

[2] Univ Buenos Aires, Fac Farm & Bioquim, Dept Farmacol, Catedra Farmacobotan, Buenos Aires, Argentina

[3] Univ Buenos Aires, Fac Farm & Bioquim, Inst Tecnol Farmaceut & Biofarm InTecFyB, Buenos Aires, Argentina

来源：

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2024年 / 23卷 / 01期

关键词：

Baccharis spicata; Hepatitis B virus; Antiviral activity; Pharmacological validation; Ethnomedical uses; AERIAL PARTS; INHIBITION; INTEGRASE; EXTRACTS; ACID;

D O I：

10.37360/blacpma.24.23.1.11

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Medicinal plants are used to cure diseases, and their replacement is frequent and affects public health. The genus Baccharis has representatives within the medicinal flora of Argentina, although the replacement of the species of this genus known under the vulgar name of "carqueja" by Baccharis spicata has been detected in herbalists or markets of herbal products. The genotoxic safety of this species has been established in previous work of our group. The aim of this study was to evaluate the antiviral activity of an infusion made from B. spicata leaves against hepatitis B virus with the HepG2.2.15 cellular system and to determine cytotoxicity in HepG2.2,15, A549 and Vero cell lines. Infusion of B. spicata was active to inhibit HBV replication with an EC50 of 22.54 mu g/mL and a CC50 of 190 mu g/mL.

引用

页码：152 / 159

页数：8

共 36 条

[1] Agudelo I.J., 2020, Dominguezia, V36, P25
[2] Agudelo IJ, 2021, Phytomed Plus, V1, DOI [DOI 10.1016/J.PHYPLU, 10.1016/j.phyplu]
[3] [Anonymous], 2003, FARMACOPEA ARGENTINA
[4] Choleretic Properties of Baccharis spicata Aerial Parts Extracts in Male Wistar Rats
Bettucci, Gabriel R.
Rodriguez, Maria Victoria
Ferretti, Matias D.
Campagna, Maria Noel
Monti, Juan
Carnovale, Cristina E.
de Lujan Alvarez, Maria
Martinez, Maria Laura
[J]. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2020, 30 (01): : 54 - 60
[5] Toxic Elements in Different Medicinal Plants and the Impact on Human Health
Brima, Eid I.
[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2017, 14 (10):
[6] CABRERA A. L., 1993, Manual de la Flora de los alrededores de Buenos Aires
[7] Genotypes and viral variants in chronic hepatitis B: A review of epidemiology and clinical relevance
Croagh, Catherine M. N.
Desmond, Paul V.
Bell, Sally J.
[J]. WORLD JOURNAL OF HEPATOLOGY, 2015, 7 (03) : 289 - 303
[8] De la Pena MR, 2011, Catalogo de nombres comunes de la flora argentina
[9] Antiprotozoal Effect of Baccharis spicata and B. punctulata Volatile Oils and Their Active Components Against Trypanosoma cruzi
Ferretti, Matias D.
Victoria Rodriguez, Maria
Ferretti, Anabela
Nocito, Isabel
Bettucci, Gabriel R.
Sol Srebot, Maria
Larghi, Enrique L.
Laura Martinez, Maria
[J]. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2022, 32 (01): : 133 - 138
[10] Bioactive neo-clerodane diterpenoids toward Tenebrio molitor larvae from Teucrium nudicaule H and Baccharis spicata (Lam) Beill
Gallardo, O
Tonn, CE
Nieto, M
Morales, G
Giordano, OS
[J]. NATURAL PRODUCT LETTERS, 1996, 8 (03): : 189 - 197

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