Applications of engineered tumor-derived extracellular vesicles in the treatment of cancer

被引：0

作者：

Zheng, Mengyuan ^{[1
]}

Liu, Pengfei ^{[2
]}

Cai, Isabella J. ^{[3
]}

Su, Jing ^{[1
]}

Yuan, Wei-en ^{[1
]}

Qiu, Mingfeng ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Clin Coll 1, 16369 Jingshi Rd, Jinan 250014, Peoples R China

[3] Thomas Jefferson High Sch Sci & Technol, 6560 Braddock Rd, Alexandria, VA 22312 USA

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 88卷

基金：

中国国家自然科学基金;

关键词：

Tumor-derived extracellular vesicles; Drug loading; Surface functionalization; Cancer therapy; IN-VITRO; T-CELL; EXOSOMES; DELIVERY; MICROPARTICLES; MICROVESICLES; THERAPY; NANOPARTICLES; MACROPHAGES; INDUCTION;

D O I：

10.1016/j.jddst.2023.104786

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tumor-derived extracellular vesicles (TEVs) are a heterogeneous population of lipid bilayer membrane-enclosed vesicles. As a result of their natural properties to mediate cell-to-cell communication and their high physi-ochemical stability and biocompatibility, TEVs are considered an excellent carrier for a variety of therapeutic drugs such as nucleic acids and proteins, drugs, and nanomaterials. They have now emerged as a novel cell-free therapy for treating various diseases, including cancer. An increasing number of studies have shown that TEVs can be modified, engineered, or designed to improve cancer treatment efficiency, specificity, and safety. Here, we evaluate the available methods for TEVs loading and comprehensively review recent advances in strategies for surface-functionalized TEVs to achieve improved cargo loading and tumor targeting, as well as look forward to opportunities and challenges for translating engineered TEVs into clinical practice.

引用

页数：14

共 98 条

[1] HepPar1-Positive Circulating Microparticles Are Increased in Subjects with Hepatocellular Carcinoma and Predict Early Recurrence after Liver Resection [J].

Abbate, Valeria ;

Marcantoni, Margherita ;

Giuliante, Felice ;

Vecchio, Fabio M. ;

Gatto, Ilaria ;

Mele, Caterina ;

Saviano, Antonio ;

Arciuolo, Damiano ;

Gaetani, Eleonora ;

Ferrari, Maria C. ;

Giarretta, Igor ;

Ardito, Francesco ;

Riccardi, Laura ;

Nicoletti, Alberto ;

Ponziani, Francesca R. ;

Gasbarrini, Antonio ;

Pompili, Maurizio ;

Pola, Roberto .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (05)

[2] Comparative Analysis of Technologies for Quantifying Extracellular Vesicles (EVs) in Clinical Cerebrospinal Fluids (CSF) [J].

Akers, Johnny C. ;

Ramakrishnan, Valya ;

Nolan, John P. ;

Duggan, Erika ;

Fu, Chia-Chun ;

Hochberg, Fred H. ;

Chen, Clark C. ;

Carter, Bob S. .

PLOS ONE, 2016, 11 (02)

[3] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[4] Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display [J].

Antes, Travis J. ;

Middleton, Ryan C. ;

Luther, Kristin M. ;

Ijichi, Takeshi ;

Peck, Kiel A. ;

Liu, Weixin Jane ;

Valle, Jackie ;

Echavez, Antonio K. ;

Marban, Eduardo .

JOURNAL OF NANOBIOTECHNOLOGY, 2018, 16

[5] Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation [J].

Barok, Mark ;

Puhka, Maija ;

Vereb, Gyorgy ;

Szollosi, Janos ;

Isola, Jorma ;

Joensuu, Heikki .

BMC CANCER, 2018, 18

[6] Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells [J].

Bebawy, M. ;

Combes, V. ;

Lee, E. ;

Jaiswal, R. ;

Gong, J. ;

Bonhoure, A. ;

Grau, G. E. R. .

LEUKEMIA, 2009, 23 (09) :1643-1649

[7] Interleukin 3-receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth [J].

Bellavia, Daniele ;

Raimondo, Stefania ;

Calabrese, Giovanna ;

Forte, Stefano ;

Cristaldi, Marta ;

Patinella, Agostina ;

Memeo, Lorenzo ;

Manno, Mauro ;

Raccosta, Samuele ;

Diana, Patrizia ;

Cirrincione, Girolamo ;

Giavaresi, Gianluca ;

Monteleone, Francesca ;

Fontana, Simona ;

De Leo, Giacomo ;

Alessandro, Riccardo .

THERANOSTICS, 2017, 7 (05) :1333-1345

[8] Engineered Exosome-Mediated Near-Infrared-II Region V2C Quantum Dot Delivery for Nucleus-Target Low-Temperature Photothermal Therapy [J].

Cao, Yu ;

Wu, Tingting ;

Zhang, Kai ;

Meng, Xiangdan ;

Dai, Wenhao ;

Wang, Dongdong ;

Dong, Haifeng ;

Zhang, Xueji .

ACS NANO, 2019, 13 (02) :1499-1510

[9] Targeting macrophages: therapeutic approaches in cancer [J].

Cassetta, Luca ;

Pollard, Jeffrey W. .

NATURE REVIEWS DRUG DISCOVERY, 2018, 17 (12) :887-904

[10] Monitoring HSP70 exosomes in cancer patients' follow up: a clinical prospective pilot study [J].

Chanteloup, Gaetan ;

Cordonnier, Marine ;

Isambert, Nicolas ;

Bertaut, Aurelie ;

Hervieu, Alice ;

Hennequin, Audrey ;

Luu, Maxime ;

Zanetta, Sylvie ;

Coudert, Bruno ;

Bengrine, Leila ;

Desmoulins, Isabelle ;

Favier, Laure ;

Lagrange, Aurelie ;

Pages, Pierre-Benoit ;

Gutierrez, Ivan ;

Lherminier, Jeanine ;

Avoscan, Laure ;

Jankowski, Clementine ;

Rebe, Cedric ;

Chevriaux, Angelique ;

Padeano, Marie-Martine ;

Coutant, Charles ;

Ladoire, Sylvain ;

Causeret, Sylvain ;

Arnould, Laurent ;

Charon-Barra, Celine ;

Cottet, Vanessa ;

Blanc, Julie ;

Binquet, Christine ;

Bardou, Marc ;

Garrido, Carmen ;

Gobbo, Jessica .

JOURNAL OF EXTRACELLULAR VESICLES, 2020, 9 (01)

← 1 2 3 4 5 6 7 8 9 10 →