Oncogenic Viruses and the Epigenome: How Viruses Hijack Epigenetic Mechanisms to Drive Cancer

被引：13

作者：

MacLennan, Signe A. ^{[1
,2
,3
]}

Marra, Marco A. ^{[1
,2
,3
]}

机构：

[1] Univ British Columbia, Dept Med Genet, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

[3] BC Canc, Canadas Michael Smith Genome Sci Ctr, Vancouver, BC V5Z 4S6, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 11期

基金：

加拿大健康研究院;

关键词：

oncogenic viruses; epigenome dysregulation; viral oncoproteins; DNA methylation; histone post-translational modifications; non-coding RNAs; histone deacetylase inhibitors; EPSTEIN-BARR-VIRUS; PAPILLOMAVIRUS TYPE-16 DNA; HISTONE DEACETYLASE INHIBITORS; E-CADHERIN EXPRESSION; KAPOSIS-SARCOMA; HEPATOCELLULAR-CARCINOMA; SFRP GENES; X PROTEIN; METHYLATION PATTERNS; MEDIATED REPRESSION;

D O I：

10.3390/ijms24119543

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Globally, viral infections substantially contribute to cancer development. Oncogenic viruses are taxonomically heterogeneous and drive cancers using diverse strategies, including epigenomic dysregulation. Here, we discuss how oncogenic viruses disrupt epigenetic homeostasis to drive cancer and focus on how virally mediated dysregulation of host and viral epigenomes impacts the hallmarks of cancer. To illustrate the relationship between epigenetics and viral life cycles, we describe how epigenetic changes facilitate the human papillomavirus (HPV) life cycle and how changes to this process can spur malignancy. We also highlight the clinical impact of virally mediated epigenetic changes on cancer diagnosis, prognosis, and treatment.

引用

页数：20

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