Possible Chronic Graft-versus-host Disease in the Central Nervous System Manifesting as Cerebellar Ataxia after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

被引：1

作者：

Takahashi, Kae ^{[1
]}

Katayama, Takayuki ^{[1
]}

Ichikawa, Takaya ^{[2
]}

Matsuoka, Satomi ^{[2
]}

Kakinoki, Yasutaka ^{[2
]}

Yoneda, Makoto ^{[3
]}

Kimura, Akio ^{[4
]}

Koyama, Satoshi ^{[5
]}

Yahara, Osamu ^{[1
]}

机构：

[1] Asahikawa City Hosp, Dept Neurol, Asahikawa, Japan

[2] Asahikawa City Hosp, Dept Hematol, Asahikawa, Japan

[3] Fukui Prefectural Univ, Fac Nursing & Social Welf Sci, Eiheiji, Japan

[4] Gifu Univ, Dept Neurol, Gifu, Japan

[5] Asahikawa Rehabil Hosp, Dept Internal Med, Asahikawa, Japan

来源：

INTERNAL MEDICINE | 2023年 / 62卷 / 05期

关键词：

central nervous system; graft-versus-host disease; allogeneic hematopoietic stem cell transplantation; leukemia; ataxia; downbeat nystagmus; ANGIITIS; ENCEPHALITIS; DIAGNOSIS; CNS;

D O I：

10.2169/internalmedicine.9720-22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 44-year-old woman was admitted to our hospital with a fever, dizziness, and gait disturbance after un-dergoing allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia followed by graft-versus-host disease. She presented with cerebellar ataxia, nystagmus, and numbness of the lower extremities. Brain magnetic resonance imaging and perfusion scintigraphy showed progressive cerebellar involvement. Cerebrospinal fluid tests showed mildly elevated protein and IgG levels without pleocytosis. Anti-ganglioside antibodies were detected, but their levels did not follow the patient's clinical course. The patient did not re-spond sufficiently to steroids or other immunotherapies. We herein report the clinical characteristics of this case and a literature review.

引用

页码：779 / 786

页数：8

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