Neutrophils in Physiology and Pathology

被引：54

作者：

Aroca-Crevillen, Alejandra ^{[1
]}

Vicanolo, Tommaso ^{[1
]}

Ovadia, Samuel ^{[2
,3
]}

Hidalgo, Andres ^{[1
,2
,3
]}

机构：

[1] Ctr Nacl & Invest Cardiovasc Carlos III CNIC, Cardiovasc Regenerat Program, Madrid, Spain

[2] Yale Univ, Vasc Biol & Therapeut Program, New Haven, CT 06520 USA

[3] Yale Univ, Dept Immunobiol, New Haven, CT 06520 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2024年 / 19卷

基金：

美国国家卫生研究院;

关键词：

neutrophil; inflammation; infection; cardiovascular disease; cancer; PEPTIDYLARGININE DEIMINASE INHIBITION; TUMOR-ASSOCIATED NEUTROPHILS; COLONY-STIMULATING FACTOR; CXCR2 ANTAGONIST AZD5069; TIMP-FREE MMP-9; EXTRACELLULAR TRAPS; BONE-MARROW; HUMAN NEUTROPENIA; CATHEPSIN-G; IN-VIVO;

D O I：

10.1146/annurev-pathmechdis-051222-015009

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Infections, cardiovascular disease, and cancer are major causes of disease and death worldwide. Neutrophils are inescapably associated with each of these health concerns, by either protecting from, instigating, or aggravating their impact on the host. However, each of these disorders has a very different etiology, and understanding how neutrophils contribute to each of them requires understanding the intricacies of this immune cell type, including their immune and nonimmune contributions to physiology and pathology. Here, we review some of these intricacies, from basic concepts in neutrophil biology, such as their production and acquisition of functional diversity, to the variety of mechanisms by which they contribute to preventing or aggravating infections, cardiovascular events, and cancer.We also review poorly explored aspects of how neutrophils promote health by favoring tissue repair and discuss how discoveries about their basic biology inform the development of new therapeutic strategies.

引用

页码：227 / 259

页数：33

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